In vitro release and the liver targeting of oxymatrine polybutylcyanoacrylate nanoparticles

Oxymatrine (OM) polybutylcyanoacrylate nanoparticles (OM-PBCA-NP) was prepared,and in vitro release of OM-PBCA-NP as well as the liver targeting potentials of OM-PBCA-NP and oxymatrine solution (OM-SOL) were studied in mice. It was found that 100% of OM was released from OM solution in 4 h,but only 36.73％ from OM-PBCA-NP. In the study of tissue distribution of OM-PBCA-NP,there existed 8.338-fold increase in the area under the liver concentration-time curve in comparison to that of OM-SOL. Hence,OM-PBCA-NP sustained drug release and increased the liver targeting significantly.