Potential mechanisms of sulfuric acid ester inositol aluminum against peptic ulcer

In this study,a chronic model of gastric ulcer by acetic acid was prepared to verify the protection of sulfuric acid ester inositol aluminum in rats.192 SD rats were randomly divided into 6 groups,and each orally given with CMC-Na,sulfuric acid ester inositol aluminum (200,400 and 800 mg/kg),talcid (400 mg/kg) and omeprazole (12 mg/kg),respectively.16 rats in each group were sacrificed separately at day 3 and day 8 after the administration;half of the 16 rats were used for the measurement of EGF,EGFR,bFGF,TGFβ,VEGF contents with the immunohistochemical staining method and another half were used for the examination of gastric ulcer index,carbon monoxide content,superoxide dismutase activity and malonaldehyde content.Compared with the model group (CMC-Na treated),the EGF, EGFR,bFGF,TGFβ,VEGF contents in the sulfuric acid ester inositol aluminum treated groups were increased obviously (P<0.05,P<0.01).Furthermore,sulfuric acid ester inositol aluminum administration was found to prevent stomach perforation,reduce the gastric ulcer index,increase the gastric ulcer inhibition rate, reduce the MDA content,and increase the SOD activity and the NO content of the organization (P<0.05). Therefore,the protection of the sulfuric acid ester inositol aluminum on gastric ulcer might be related to the increment of EGF,EGFR,bFGF,TGFβ,VEGF,NO contents,and the SOD activity as well as the reduction of MDA content.