YANG Jia-bin, CHEN Li, SU Guo-qiang, REN Yu. Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(2): 107-111.
Citation:
YANG Jia-bin, CHEN Li, SU Guo-qiang, REN Yu. Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(2): 107-111.
YANG Jia-bin, CHEN Li, SU Guo-qiang, REN Yu. Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(2): 107-111.
Citation:
YANG Jia-bin, CHEN Li, SU Guo-qiang, REN Yu. Synthesis and tubulin polymerization inhibitory activity of osthol stilbene derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(2): 107-111.
A series of novel osthole stilbene derivatives were synthesized,and their structures were determined by MS and 1H NMR.The tubulin polymerization inhibitory activity of the synthesized compounds was evaluated using anti-human umbilical vein endothelial cells in vitro.Preliminary results showed that compound Ⅵ7 was the most potent inhibitor,but was less potent than combretastatin A-4.Compound Ⅵ7 is a promising compound worthy of further studies.