Drug loading and solidification of Pluronic F127 micellar solution and dissolution of its tablets

The purposes of this study were to prepare simvastatin (SIM)-loading Pluronic F127 (F127) micellar solution and to study the solidification of the solution as an oral dosage form.Film-hydration method was used to prepared simvastatin (SIM)-loading F127 micellar solution, whose processing parameters were optimized using orthogonal design and drug loading efficiency.Then the drug-loaded micelle solution was solidificated with spray-drying, and the resultant powders were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD).Aqueous reconstitution of the solidified micellar powders was performed, and the dissolution of tablet containing SIM-F127 micelles was carried out in comparison to commercially available tablets.It was indicated that the solubility of SIM in the micellar solution increased 950 times and that the loading efficiency reached 13%.The amorphous characteristics and good flow property were evident using the spray drying powders.Once upon contact with water, SIM micellar solution was spontaneously reconstituted and more stable against the temperature and dilution.In vitro dissolution test showed that SIM dissolution from the solidification micelles tablet was increased significantly if compared to that of the market tablets.