Effect of different formula compatibility of Zhizi Houpu decoction on the pharmacokinetics of naringenin and hesperetin

The objective of this paper was to obtain pharmacokinetic parameters from concentration-time data of naringenin and hesperetin in rat plasma after oral administration of different recipes of Zhizi Houpu decoction (ZZHPD) which contained HP (Magnoliae Officinalis Cortex),ZS (Aurantii Fructus Immaturus) and ZZ (Gardeniae Fructus),including ZS,ZS-ZZ (ZS and ZZ),ZS-HP (ZS and HP) and ZZHPD (ZS,ZZ and HP).The effects of different recipes of ZZHPD on the pharmacokinetics of naringenin and hesperetin in rat plasma were _{investigated.Twenty-four rats were randomly divided into four groups,and treated with ZS,ZS-ZZ,ZS-HP and ZZHPD (10.83 mL/kg),respectively.The plasma concentrations of four recipes were determined by HPLC,and the pharmacokinetic parameters of naringenin and hesperetin in these recipes were evaluated.The pharmacokin etic parameters of naringenin and hesperetin were different after oral administration of four decoctions according to ZS combined with different herbal medicines.ZZ and HP could delay the absorption of naringenin and hesperetin,and HP could significantly increase the AUC0-24 hof hesperetin; the compatible effect of herbs in ZZHPD could accelerate the absorption rate of naringenin and hesperetin,reduce the AUC0-24 hof naringenin and increase the AUC0-24 h of hesperetin with the enhancive extend less than that of ZS-HP group.The pharmacokinetic parameters of the two compounds obtained in this work showed that the pharmacokinetics of naringenin and hesperetin were influenced diversely when ZS was combined with different herbal medicines.}