Effects of 1-(cinnamoyl)-4-(phenylethylamine acetyl) piperazine maleate on platelet aggregation and thrombosis

This study was to investigate the effects of 1-(cinnamoyl)-4-(phenylethylamine acetyl) piperazine maleate on antiplatelet and anticoagulant.The bleeding time was measured by tail cutting method and clotting time was determined by slide method.The thrombosis inhibition was observed by arterio-venous shunt model in rats.Platelet aggregation in vivo and in vitro were induced by ADP and determined by an aggregometer to measure the maximum platelet aggregation in rabbits.The results indicated that,1-(cinnamoyl)-4-(phenylethylamine acetyl) piperazine maleate significantly inhibited coagulation,thrombus formation and platelet aggregation induced by ADP.