Inhibition of Hainan holly leaf extract on rats with experimental benign prostatic hyperplasia

48 rats were randomly divided into 6 groups：a normal control group，a model group of benign prostatic hyperplasia(BPH) treated by subcutaneous injection of testosterone propionate，a positive control group (rat in model group treated with Qianliekang by orally) and Hainan holy leaf extract (HHLE) groups (rat in model group treated with HHLE by orally).After treating 5 weeks，the rat prostate wet weight，the index of prostate gland(PI)，the serum acid phosphatase (ACP)，non-prostate-specific acid phosphatase (NPAP) and PAP were measured.Morphological changes of the prostate tissue under optical microscope were observed.Results showed that prostate wet weight，PI and serum PAP of high and medium dose groups were obviously decreased compared with the model group，with a significant difference （P＜0.01） similar to that of Qianliekang.High-doses group (80 mg/kg) improved the morphological changes of the prostate characterized by reducing interstitial fibrosis，increasing secretions in the glandular cavity and prostate calculi showing eosinophilic，which were similar to those of the normal group.HHLE has inhibitive effect on BPH induced by testosterone propionate in rats.