• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
BAI Li, NIU Xiao-shu, XIONG Jing, FANG Wei-rong, LI Yun-man. Inhibition of pENW on arterial thrombosis induced by FeCl3 in rat[J]. Journal of China Pharmaceutical University, 2012, 43(1): 75-78.
Citation: BAI Li, NIU Xiao-shu, XIONG Jing, FANG Wei-rong, LI Yun-man. Inhibition of pENW on arterial thrombosis induced by FeCl3 in rat[J]. Journal of China Pharmaceutical University, 2012, 43(1): 75-78.
shu

Inhibition of pENW on arterial thrombosis induced by FeCl3 in rat

More Information
    Graphical Abstract
    • Abstract
  • The model of arterial thrombosis induced by FeCl3 in rat was used to investigate the antithrombotic effect of pGlu-Asn-Trp（pENW）.Platelet aggregation was tested according to Born’s methods.Platelet cytosolic calcium was determined using of Fura-2/AM.Prothrombin time (PT)，thrombin time (TT) and activated partial thromboplastin time (APTT) were tested for exploring the effect of pENW on prothrombin.pENW (iv) inhibited arterial thrombosis induced by FeCl3 and platelet aggregation induced by ADP,respectively (P<0.05).Ex vivo pENW markedly lowered the cytosolic calcium higher concentration induced by ADP in platelet.However，there was no significant effect on PT，TT and APTT.These results showed that pENW evidently inhibited platelet aggregation and decreased the concentration of platelet cytosolic calcium.Results suggest that the antithrombotic effect of pENW may be related to its anti-platelet aggregation and the decrease of platelet cytosolic calcium.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]HUANG Zhihuan, LIANG Xiao, GAO Xiangdong, CHEN Song. Effects and mechanisms of SNP-9 on Parkinson''s disease cell model induced by rotenone[J]. Journal of China Pharmaceutical University, 2023, 54(2): 238-244. DOI: 10.11665/j.issn.1000-5048.2023020101
    [2]Studies on the Transdermal Absorption of Aminophylline Film and Its Therapeutic Effects on Asthma[J]. Journal of China Pharmaceutical University, 1995, (2): 81-83.
    [3]Studies on Films for the Treatment of Cough and Asthma[J]. Journal of China Pharmaceutical University, 1994, (4): 29-31.
    [5]COMPARISON OF SPERMICIDAL ACTIVITY OF DEFFERENT PRODUCTS OF NONOXYNOL-9[J]. Journal of China Pharmaceutical University, 1987, (4): 297-300.
    [6]STUDY OF PREPARATION ON CONTRACEPTIVE CREAM AND ITS PERCUTANEOUS ABSORPTION[J]. Journal of China Pharmaceutical University, 1987, (4): 247-250.
    [7]DETERMINATION OF GLYCERIN TRINITRATE IN NITROGLYCERIN TRANSDERMAL FILMS BY HPLC[J]. Journal of China Pharmaceutical University, 1987, (2): 124-125.
    [8]DETERMINATION OF RELEASE RATE,MYOTIC ACTIVITY AND IRRITATION OF CONTROLLED- RELEASE PILOCARPINE OPHTHALMIC FILM[J]. Journal of China Pharmaceutical University, 1985, (1): 21-27.
    [9]Dong Shanshi, Yang Zhongyuan, An Dengkui. Comparative Study of the Determination of Nonyl phenoxy-polyoxyethylethanol in Contraceptive Film.[J]. Journal of China Pharmaceutical University, 1980, (2): 64-70.
    [10]Yang Zhongyuan, Dong Shanshi, An Dengkui. Determination of Nonylphenoxylpolyoxyethylethanol in Contraceptive Films by Orthogonal Functions Method[J]. Journal of China Pharmaceutical University, 1980, (1): 54-57.

Catalog

    Get Citation
    PDF
    XML
    Article views (1615) PDF downloads (2192) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：308775

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return