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WU Jian-ping, HE Ling-yun, YUN Jun-jun, CHEN Jun, HU Gao-yun. Confirmation and quality control of a photoploymerized substance in fluorofenidone[J]. Journal of China Pharmaceutical University, 2012, 43(2): 159-163.
Citation: WU Jian-ping, HE Ling-yun, YUN Jun-jun, CHEN Jun, HU Gao-yun. Confirmation and quality control of a photoploymerized substance in fluorofenidone[J]. Journal of China Pharmaceutical University, 2012, 43(2): 159-163.

Confirmation and quality control of a photoploymerized substance in fluorofenidone

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  • The solid state reaction was used to prepare a photoploymerized substance from fluorofenidone.The photoploymerized substances were separated and purified by pre-HPLC.The spectral analyses,such as UV,MS,13C NMR,1H-1H COSY,HMBC and HMBQ were used to identify the structure of the photoploymerized substances.The HPLC method was established to determine the photoploymerized substance.The chromatographic conditions were as follows:Kromasil C18column (4.6 mm×250 mm,5 μm) was used and the column temperature was 30 °C.Acetonitrile-water (55 ∶45) containing 0.1% triethylamine,which was adjusted to pH 4.0 by methanesulfonic acid,was used as the mobile phase with a flow rate of 1.0 mL/min;the detection wavelength was 230 nm.The results showed that fluorofenidone is photosensitive and the method is specific and accurate.

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