Advanced Search
REN Xin-yi, CHEN Yuan-cheng, WANG Yan, XIAO Yuan-yuan, LIU Xiao-quan. Pharmacokinetic-pharmacodynamic(PK-PD) modeling of salvianolic acid A on the plasma homocysteine in rats[J]. Journal of China Pharmaceutical University, 2012, 43(3): 260-265.
Citation: REN Xin-yi, CHEN Yuan-cheng, WANG Yan, XIAO Yuan-yuan, LIU Xiao-quan. Pharmacokinetic-pharmacodynamic(PK-PD) modeling of salvianolic acid A on the plasma homocysteine in rats[J]. Journal of China Pharmaceutical University, 2012, 43(3): 260-265.

Pharmacokinetic-pharmacodynamic(PK-PD) modeling of salvianolic acid A on the plasma homocysteine in rats

More Information
  • Elevated plasma total homocysteine (tHcy) level has been acknowledged as an independent risk factor for cardiovascular diseases.Salvianolic acid A (SalA) is one of the major active water-soluble ingredients of Salvia miltiorrhiza.The pharmacokinetics (PK) and pharmacodynamics (PD) of SalA on plasma tHcy in methionine-loading rats was evaluated.Acute treatment with a single dose of SalA (1,2.5,5 mg/kg) in rats with Met loading significantly reduced the plasma tHcy level in a dose-dependent manner.In order to characterize the effect of SalA on plasma tHcy,a mechanism-based PK-PD model was developed.Modeling and simulations well fitted the measured values.By comparison with the PK-PD model of danshensu(DSS),it was found that the elevated effect of SalA on tHcy by methylation was weaker than that of DSS,while trans-sulfuration promotion effect of SalA on tHcy was greater than that of DSS.
  • Related Articles

    [1]YAN Yuting, LAI Changjiangsheng, LI Ping, CHEN Jun. Metabolites of salvianolic acid C in rats in vivo[J]. Journal of China Pharmaceutical University, 2013, 44(5): 442-446. DOI: 10.11665/j.issn.1000-5048.20130511
    [5]Effect of ZLR-8 on the Healing of Gastric Ulcer and NO Releasing in vitro[J]. Journal of China Pharmaceutical University, 2004, (4): 67-70.
    [6]Everted Gut Sac as a Technique to Study the Absorption Behavior of Cyclosporin A Nanoliposome[J]. Journal of China Pharmaceutical University, 2003, (2): 41-44.
    [7]Absorption of Breviscapine in Small Intestine of Rat[J]. Journal of China Pharmaceutical University, 2003, (1): 67-71.
    [8]Experimental Study on Ginkgo Biloba Extract Against Carbon Tetrachloride-induced Chronic Liver Damage in Rats[J]. Journal of China Pharmaceutical University, 2003, (1): 63-66.
    [9]Absorption of PancreaticKininogenase from the Perfused Rat Colon[J]. Journal of China Pharmaceutical University, 2001, (2): 29-31.

Catalog

    Article views (1375) PDF downloads (2059) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return