• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
REN Xin-yi, CHEN Yuan-cheng, WANG Yan, XIAO Yuan-yuan, LIU Xiao-quan. Pharmacokinetic-pharmacodynamic(PK-PD) modeling of salvianolic acid A on the plasma homocysteine in rats[J]. Journal of China Pharmaceutical University, 2012, 43(3): 260-265.
Citation: REN Xin-yi, CHEN Yuan-cheng, WANG Yan, XIAO Yuan-yuan, LIU Xiao-quan. Pharmacokinetic-pharmacodynamic(PK-PD) modeling of salvianolic acid A on the plasma homocysteine in rats[J]. Journal of China Pharmaceutical University, 2012, 43(3): 260-265.
shu

Pharmacokinetic-pharmacodynamic(PK-PD) modeling of salvianolic acid A on the plasma homocysteine in rats

More Information
    Graphical Abstract
    • Abstract
  • Elevated plasma total homocysteine (tHcy) level has been acknowledged as an independent risk factor for cardiovascular diseases.Salvianolic acid A (SalA) is one of the major active water-soluble ingredients of Salvia miltiorrhiza.The pharmacokinetics (PK) and pharmacodynamics (PD) of SalA on plasma tHcy in methionine-loading rats was evaluated.Acute treatment with a single dose of SalA (1,2.5,5 mg/kg) in rats with Met loading significantly reduced the plasma tHcy level in a dose-dependent manner.In order to characterize the effect of SalA on plasma tHcy，a mechanism-based PK-PD model was developed.Modeling and simulations well fitted the measured values.By comparison with the PK-PD model of danshensu(DSS)，it was found that the elevated effect of SalA on tHcy by methylation was weaker than that of DSS,while trans-sulfuration promotion effect of SalA on tHcy was greater than that of DSS.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]Studies on Pharmacokinetics and Relative Bioavailability of Aceclofenac Controlled-Release Tablets in Dogs[J]. Journal of China Pharmaceutical University, 2004, (5): 57-59.
    [2]Relative Bioavailability and Pharmacokinetics of Roxithromycin Dispersive Tablets in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 2004, (4): 41-43.
    [3]Pharmacokinetics and Bioavailability of Cinnamic Acid in Mice[J]. Journal of China Pharmaceutical University, 2004, (4): 38-40.
    [4]Preparation of Sodium Valproate Sustained-Release Tablets and Evaluation on its Bioavailability in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 2000, (6): 22-25.
    [5]Pharmacokinetics and Relative Bioavailability of Gliquidone Capsules and Tablets[J]. Journal of China Pharmaceutical University, 2000, (6): 19-21.
    [6]Pharmacokinetics andRelative Bioavailability of Sustained-release Felodipine Capsule in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 2000, (3): 26-29.
    [7]Preparation of Naproxen Sustained Release Tablets and Evaluation on its Bioavailability in Healthy Human Volunteers[J]. Journal of China Pharmaceutical University, 1999, (2): 12-15.
    [8]Study on Pharmacokinetics and Relative Bioavailability of Cefaclor Sustained Release Tablets in 8 Chinese Healthy Subjects[J]. Journal of China Pharmaceutical University, 1998, (5): 29-32.
    [9]Pharmacokinetics and Relative Bioavailability of Cyclosporin Pearls in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1996, (6): 20-22.
    [10]Pharmacokinetics and Relative Bioavailability of Tamoxifen in Healthy Volunteers[J]. Journal of China Pharmaceutical University, 1995, (2): 84-86.

Catalog

    Get Citation
    PDF
    XML
    Article views (1367) PDF downloads (2058) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：320205

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return