Correlation of Fuzilizhong chemome release from osmotic pump tablets and intrinsic dissolution characteristics from powders

To investigate the effects of formula factors such as osmotic agents,disintegrating agents and preparation process on the Fuzilizhong chemome release from osmotic pump tablets.The total ultraviolet absorbance value of all the components was as the release indexes,the surface dissolution/erosion imaging system was used to determine the intrinsic dissolution characteristics of the powders.The correlation between the chemome release from osmotic pump tablets and the intrinsic dissolution characteristics of the powders was established.From the results of the chemomic release study,the optimized formulation of the osmotic pump tablets had lactose and sodium chloride (weight ratio 1∶1) as osmotic agents,5% crosslinking polyvingypyrrolidone (PVPP) as disintegrating agent.It was indicated from the correlation analysis that there was a negative correlation between the intrinsic dissolution rate of powders and the dissolution rate of osmotic pump tablets,and a linear correlation between powders intrinsic dissolution rate and the amount of PVPP.However,excessive PVPP could affect the maximum cumulative release.