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FANG Chang-jin, SONG Min, HANG Tai-jun, ZHANG Xiao-lei, SU Hao-ming, JIANG Cui-cui. Pharmacokinetics of berberine,jatrorrhizine and palmatine in Beagle dogs after oral administration of Ermiao Wan[J]. Journal of China Pharmaceutical University, 2012, 43(5): 438-442.
Citation: FANG Chang-jin, SONG Min, HANG Tai-jun, ZHANG Xiao-lei, SU Hao-ming, JIANG Cui-cui. Pharmacokinetics of berberine,jatrorrhizine and palmatine in Beagle dogs after oral administration of Ermiao Wan[J]. Journal of China Pharmaceutical University, 2012, 43(5): 438-442.

Pharmacokinetics of berberine,jatrorrhizine and palmatine in Beagle dogs after oral administration of Ermiao Wan

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  • This study developed an LC-MS/MS method for the simultaneous determination and plasma pharmacokinetic study of berberine,jatrorrhizine and palmatine in beagle dogs after oral administration of Ermiao Wan.Six dogs (3 males and 3 females) were orally administered with Ermiao wan (equal to berberine 25mg/kg).Blood samples were collected into heparinized tubes from 0 to 48 h.The detection was performed by positive electrospray ionization (ESI) in the selected reaction monitoring mode.The main pharmacokinetic parameters of berberine,jatrorrhizine and palmatine were obtained as follows:cmax(4.474±1.8),(0.508 3±0.2) and (0.812 4±0.7) ng/mL,t1/2(38.1±15.4),(23.8±9.9) and (20.2±17.1) h,AUC0-48 h(37.4±3.9),(3.75±1.2) and (3.01±0.9) ng·h/mL.The results indicated that the oral bioavailability of berberine,jatrorrhizine and palmatine were very low.They were absorbed rapidly,and eliminated slowly in vivo.
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