• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
WANG Zhenghua, LIANG Tong, LI Tao, ZHOU Keyuan. Effect of chrysin in inhibiting proliferation of human nasopharyngeal carcinoma cell line CNE-2[J]. Journal of China Pharmaceutical University, 2013, 44(1): 93-96. DOI: 10.11665/j.issn.1000-5048.20130116
Citation: WANG Zhenghua, LIANG Tong, LI Tao, ZHOU Keyuan. Effect of chrysin in inhibiting proliferation of human nasopharyngeal carcinoma cell line CNE-2[J]. Journal of China Pharmaceutical University, 2013, 44(1): 93-96. DOI: 10.11665/j.issn.1000-5048.20130116
shu

Effect of chrysin in inhibiting proliferation of human nasopharyngeal carcinoma cell line CNE-2

More Information
    Graphical Abstract
    • Abstract
  • The aim of the study was to investigate the inhibition effect of chrysin on the growth of human nasopharyngeal darcinoma CNE-2 cells.The cell proliferation was determined by CCK-8;the apoptosis bodies were observed by Hoechst 33258 staining;the apoptosis was detected by flow cytometry;and the activity of caspase-3 was analyzed by caspase-3 activity assay kit.The proliferation of CNE-2 cells was inhibited by chrysin in the concentration and time-dependent manners.Chrysin induced the apoptosis of CNE-2 cells.Furthermore，chrysin dramatically induced G0/G1 phase cell increase and S phase cell decrease.Cell cycle was arrested at G0/G1 phase.Chrysin could elevate the caspase-3 activity observably.Chrysin markedly inhibited the proliferation of CNE-2 cells.The inhibition effect may be related to inducing the apoptosis and cell cycle arrest on CNE-2 cells.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]LIU Meishuo, WANG Haina, LONG Feida, LENG Nan, YANG Yongliang. Screening of a novel CRM1 targeting inhibitor and its effects on the proliferation and growth of extranodal NK/T cell lymphoma[J]. Journal of China Pharmaceutical University, 2020, 51(1): 44-51. DOI: 10.11665/j.issn.1000-5048.20200108
    [2]LIU Kunmei, GUO Le, XI Tao. Mechanism study on apoptosis of hepatocellular carcinoma HepG2 cells induced by ursolic acid through inhibiting the expression of miR-21[J]. Journal of China Pharmaceutical University, 2015, 46(6): 745-750. DOI: 10.11665/j.issn.1000-5048.20150619
    [3]FENG Quanfu, BI Lei, YAN Xiaojing, YANG Ye, CHEN Weiping. Inhibition of tetramethypyrazine on proliferation of HepG2 cells and its effects on the pathway of mitochondrial apoptosis[J]. Journal of China Pharmaceutical University, 2015, 46(3): 350-354. DOI: 10.11665/j.issn.1000-5048.20150315
    [4]GU Yi, LI Xiaoman, ZHENG Lufeng, YANG Jue, XI Tao. MicroRNA-10b regulates proliferation, cell cycle and apoptosis in human breast cancer cells[J]. Journal of China Pharmaceutical University, 2015, 46(2): 242-249. DOI: 10.11665/j.issn.1000-5048.20150218
    [5]ZHANG Xiaoling, LI Aiping, HUAN Fei, QIN Heng, DUAN Jin′ao. Effects of celastrol on the proliferation and apoptosis of human leukemia cells HL-60 and Jurkat[J]. Journal of China Pharmaceutical University, 2015, 46(1): 89-93. DOI: 10.11665/j.issn.1000-5048.20150113
    [6]HE Shuying, SUN Jing, LIU Kun, XU Yungen. Effect of combretastatin A-4 derivative CPU-XT-006 on proliferation, apoptosis and expression of VEGF and bFGF of HUVEC in vitro[J]. Journal of China Pharmaceutical University, 2013, 44(5): 451-454. DOI: 10.11665/j.issn.1000-5048.20130513
    [7]CHEN Min, ZHANG Zhen-zhen, DING Ye, ZHANG Yi-hua, JI Hui. Effects of NO-donating oleanane derivatives on cell proliferation and apoptosis of human hepatoma cell lines[J]. Journal of China Pharmaceutical University, 2011, 42(3): 247-250.
    [8]WANG Wei, YAO Jing, ZHOU Jian-ping, LI Yi-ping, TAO Lei. Effects of urocanic acid-modified chitosan-mediated wild-type p53 gene transfection on proliferation and apoptosis of human lung adenocarcinoma cell line H1299[J]. Journal of China Pharmaceutical University, 2009, 40(5): 440-444.
    [9]GUO Zhong, ZHAO Jin, MA Jian-xiu, FU Si-wu. Effects of toxin A from Clostridium difficile on SMMC-7721 cells proliferation and apoptosis[J]. Journal of China Pharmaceutical University, 2009, 40(3): 250-253.
    [10]The Effects ofPolysaccharide from Porphyra Yezoensis Ueda on Proliferation of Lymphocytes[J]. Journal of China Pharmaceutical University, 2001, (1): 59-61.

Catalog

    Get Citation
    PDF
    XML
    Article views (1224) PDF downloads (1715) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：295151

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return