• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
REN Hancheng, JIANG Fan, FAN Qingming, YUAN Lei, QIAN Zhiying, ZHAO Hailong. Determination of the related substances of atorvastatin calcium and intermediate L1 by HPLC[J]. Journal of China Pharmaceutical University, 2014, 45(1): 70-75. DOI: 10.11665/j.issn.1000-5048.20140112
Citation: REN Hancheng, JIANG Fan, FAN Qingming, YUAN Lei, QIAN Zhiying, ZHAO Hailong. Determination of the related substances of atorvastatin calcium and intermediate L1 by HPLC[J]. Journal of China Pharmaceutical University, 2014, 45(1): 70-75. DOI: 10.11665/j.issn.1000-5048.20140112
shu

Determination of the related substances of atorvastatin calcium and intermediate L1 by HPLC

More Information
    Graphical Abstract
    • Abstract
  • To investigate the related substances of atorvastatin calcium(ATV-Ca)and it′s key intermediate L1, 14 related substances were synthesized, and an HPLC method was developed by using a C18 column, the mobile phase of H2O-CH3CN-THF-MeOH(36 ∶8. 4 ∶29 ∶26. 6), and the detection wavelength of 246 nm. There were 4 potential impurities in intermediate L1 and 10 potential impurities in ATV-Ca; The established methods were accurate and reproducible, which could be used for analysing the related substances in atorvastatin calcium and its key intermediate L1.
    • FullText(HTML)
    • References (5)
  • [1]
    Xia ZJ,Ma YQ,Lin S,et al.Total synthesis of(3S,5R)-epimers of atorvastatin calcium[J].Guangdong Chem Ind(广东化工杂志),2012,10(39):29-30.
    [2]
    Zhang MY, Sun GX. Content determination and related substances of 3 kinds of intermediates of atorvastatin calcium by HPLC[J].J China Pharm(中国药房),2013,24(1):83-85.
    [3]
    Zhang YP,Yang SL,Chen FE,et al.HPLC determination of related substances and enantiomeric purity of atorvastatin calcium[J].Chin J Pharm Anal(药物分析杂志),2010,30(12):2 311-2 313.
    [4]
    Indian Pharmacopoeia Commission.Indian Pharmacopoeia:volume 2[M].Ghaziabad:Indian Pharmacopoeia Commission,2010:849-851.
    [5]
    Gupta LK.Spectroscopic characterization and quantitative determination of atorvastatin calcium impurities by novel HPLC method[J].Spectrochim Acta A Mol Biomol Spectrosc,2012,97:495-501.
    • Related Articles

  • Related Articles

    [1]LI Long, GUO Wei, YU Xiuli, XIE Chunwen. Determination of the related substances in desloratadine by HPLC[J]. Journal of China Pharmaceutical University, 2019, 50(6): 707-712. DOI: 10.11665/j.issn.1000-5048.20190611
    [2]AN Jiong, LI Kan, XU Xiaoming, GAO Zhun, HU Chao, LI Bo, DI Bin, XU Lili. Development and validation of a novel and simple RP-HPLC method for the determination of related substances of tiopronin for injection[J]. Journal of China Pharmaceutical University, 2019, 50(3): 317-324. DOI: 10.11665/j.issn.1000-5048.20190307
    [3]ZHAO Xun, SHAO Fangxian, YUAN Yaozuo, ZHANG Mei, TAN Li. Determination of the related substances of benzyl hydroxybenzoate by RP-HPLC[J]. Journal of China Pharmaceutical University, 2017, 48(3): 317-321. DOI: 10.11665/j.issn.1000-5048.20170311
    [4]LIU Chao, ZHONG Xing, XI Yanqiong, TANG Yinxia, JIANG Li, WANG Fujun, PU Tong, ZENG Su. Determination of the related substances of tenofovir by RP-HPLC[J]. Journal of China Pharmaceutical University, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
    [5]ZHAO Xun, YUAN Yaozuo, ZHANG Mei, TAN Li. Determination of pyrazinamide and its related substances by HPLC[J]. Journal of China Pharmaceutical University, 2013, 44(6): 536-539. DOI: 10.11665/j.issn.1000-5048.20130609
    [6]XU Ying, WU Qiong-zhu, KE Xue. Determination of moxifloxacin hydrochloride and its related substances by HPLC[J]. Journal of China Pharmaceutical University, 2012, 43(1): 46-50.
    [7]HAN Jia-yi, ZHANG Yun, WANG Xin-yue. RP-HPLC gradient elution analysis for the determination of pantoprazole soldium and its related substances[J]. Journal of China Pharmaceutical University, 2009, 40(6): 531-534.
    [8]ZHANG Jin-lin, YUAN Yao-zuo, QIAN Wen, ZHANG Mei. Determination of secnidazole and its related substances by HPLC[J]. Journal of China Pharmaceutical University, 2009, 40(6): 527-530.
    [9]Determination of Ganciclovir and Its Related Substances by HPLC[J]. Journal of China Pharmaceutical University, 2004, (2): 38-40.
    [10]The Comparison of Determinating Cyclovirobuxine D Related Substances by HPLC/MS and Precolumn Derivatization on RP-HPLC Using 1-phenyl-isocyanate[J]. Journal of China Pharmaceutical University, 2002, (5): 55-58.

Catalog

    Get Citation
    PDF
    XML
    Article views (1540) PDF downloads (1923) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：302626

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return