Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats

YOU Meigui; CHEN Tong; NI Yuanning; JI hui

doi:10.11665/j.issn.1000-5048.20140119

Journal of China Pharmaceutical University > 2014 > 45(1): 102-105. > DOI: 10.11665/j.issn.1000-5048.20140119

YOU Meigui, CHEN Tong, NI Yuanning, JI hui. Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats[J]. Journal of China Pharmaceutical University, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119

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Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats

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The study was designed to investigate the effect of compound ursodeoxycholic acid oral liquid(C-UDCA)on acute intrahepatic cholestasis in rats, which was induced by α-naphthylisothiocyanate(ANIT, 150 mg/kg). The effects of C-UDCA were examined by serological determination, histological assessment of liver damage and bile excretion experiments. Results demonstrated that the administration of C-UDCA could significantly ameliorate ANIT-induced bile duct injury, cholestasis and hepatocytic damage. Compared with ursodeoxycholic acid(UDCA), high and mediumdoses of C-UDCA could remarkably reduce the elevated serum levels of alanine aminotransferase(ALT), while greatly enhancing the activity of Na⁺-K⁺-ATPase and SOD in liver tissues. All taken together, our data suggested that C-UDCA exhibited a better hepatoprotective effect against ANIT-induced cholestasis than UDCA.
- compound ursodeoxycholic acid oral liquid,
- cholestatic hepatitis,
- α-naphthylisothiocyanate

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Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats

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