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YOU Meigui, CHEN Tong, NI Yuanning, JI hui. Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats[J]. Journal of China Pharmaceutical University, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119
Citation: YOU Meigui, CHEN Tong, NI Yuanning, JI hui. Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats[J]. Journal of China Pharmaceutical University, 2014, 45(1): 102-105. DOI: 10.11665/j.issn.1000-5048.20140119
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Effect of compound ursodeoxycholic acid oral liquid on cholestatic hepatitis in rats

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  • The study was designed to investigate the effect of compound ursodeoxycholic acid oral liquid(C-UDCA)on acute intrahepatic cholestasis in rats, which was induced by α-naphthylisothiocyanate(ANIT, 150 mg/kg). The effects of C-UDCA were examined by serological determination, histological assessment of liver damage and bile excretion experiments. Results demonstrated that the administration of C-UDCA could significantly ameliorate ANIT-induced bile duct injury, cholestasis and hepatocytic damage. Compared with ursodeoxycholic acid(UDCA), high and mediumdoses of C-UDCA could remarkably reduce the elevated serum levels of alanine aminotransferase(ALT), while greatly enhancing the activity of Na+-K+-ATPase and SOD in liver tissues. All taken together, our data suggested that C-UDCA exhibited a better hepatoprotective effect against ANIT-induced cholestasis than UDCA.
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    • References (9)
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