• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
WANG Shu, ZHANG Zhenhai, GU Dongfei, ZHOU Jianping, LYV Huixia. Advances of exosomes as a new drug delivery system[J]. Journal of China Pharmaceutical University, 2014, 45(2): 247-252. DOI: 10.11665/j.issn.1000-5048.20140221
Citation: WANG Shu, ZHANG Zhenhai, GU Dongfei, ZHOU Jianping, LYV Huixia. Advances of exosomes as a new drug delivery system[J]. Journal of China Pharmaceutical University, 2014, 45(2): 247-252. DOI: 10.11665/j.issn.1000-5048.20140221

Advances of exosomes as a new drug delivery system

More Information
  • Exosome is a kind of immune functional membrane vesicles secreted from multivesicular body fusing with cell membrane. It contains a large number of closely related functional protein and lipid components, with the functions of cell growth proteins waste removal, signal transduction, antigen presentation, cells activation, inducing and enhancing immune response. In recent years, some researchers used exosomes as nanocarriers to avoid the possible side-effects and immune rejection of usual exogenous nanocarriers. This review briefly describes its discovery, function and development as a drug carrier with reference to some recent research papers to replenish a novel drug delivery system.
  • [1]
    Torchilin VP.Recent advances with liposomes as pharmaceutical carriers[J].Nat Rev Drug Discov,2005,4(2):145-160.
    [2]
    Simons M,Raposo G.Exosomes-vesicular carriers for intercellular communication[J].Cell Biol,2009,21(4):575-581.
    [3]
    van den Boorn JG,Schlee M,Coch C,et al.SiRNA delivery with exosome nanoparticles[J].Nat Biotechnol,2011,29(4):325-326.
    [4]
    van den Boorn JG,Dassler J,Coch C,et al.Exosomes as nucleic acid nanocarriers[J].Adv Drug Deliv Rev,2013,65(3):331-335.
    [5]
    Valenti R,Huber V,Iero M,et al.Tumor-released microvesicles as vehicles of immunosuppression[J].Cancer Res,2007,67(7):2 912-2 915.
    [6]
    Valadi H,Ekstrom K,Bossios A,et al.Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J].Nat Cell Biol,2007,9(6):654-659.
    [7]
    Ronne WYY,Ruenn CL,Zhang B,et al.Mesenchymal stem cell:an efficient mass producer of exosomes for drug delivery[J].Adv Drug Deliv Rev,2013,65(3):336-341.
    [8]
    Couzin J.Cell biology:the ins and outs of exosomes[J].Science,2005,308(5 730):1 862-1 863.
    [9]
    Orr L, Adam M, Rose J. Externalization of membrane-bound activities during sheep reticulocyte maturation is temperature and ATP dependent[J].Biochem Cell Biol,1987,65(12):1 080-1 090.
    [10]
    Mitchell P,Petfalski E,Shevchenko A,et al.The exosome:a conserved eukaryotic RNA processing complex containing multiple 3′→5′ exoribonucleases[J].Cell,1997,91(4):457-466.
    [11]
    Li XB, Zhang ZR, Schluesener HJ, et al. Role of exosomes in immune regulation[J].Cell Mol Med,2006,10(2):364-375.
    [12]
    Camussi G,Deregibus MC,Bruno S,et al.Exosome/microvesicle-mediated epigenetic reprogramming of cells[J].Am J Cancer Res,2011,1(1):98-110.
    [13]
    Aaron T,Jayakumar R,Alexander M.Seifalian exosomes as nano-theranostic delivery platforms for gene therapy[J].Adv Drug Deliv Rev,2013,65(3):357-367.
    [14]
    Heijnen HF, Schiel AE, Fijnheer R, et al. Activated platelets release two types of membrane vesicles:microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules[J].Blood,1999,94(11):3 791-3 799.
    [15]
    Street JM,Barran PE,MacKay CL,et al.Identification and proteomic profiling of exosomes in human cerebrospinal fluid[J].Transl Med,2012,10:5.doi: 10.1186/1479-5876-10-5.
    [16]
    Clayton A,Mason MD.Exosomes in tumour immunity[J].Curr Oncol,2009,16(3):46-49.
    [17]
    Van den Broeke LT,Daschbach E,Thomas EK,et al.Dendritic cell—induced activation of adaptive and innate antitumor immunity[J].Immunol,2003,171(11):5 842-5 852.
    [18]
    Alvarez-Erviti L,Seow Y,Yin H,et al.Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes[J].Nat Biotechnol,2011,29(4):341-345.
    [19]
    Du Y,Chen SQ,Huang YM,et al.Exosomes and dendritic cells derived from PBMCs of intracranial malignant glioma patients induce T-cell proliferation and CTL cytotoxicity[J].Immunol J(免疫学杂志),2006,22(6):664-667.
    [20]
    Lai RC,Arslan F,Tan SS,et al.Derivation and characterization of human fetal MSCs:an alternative cell source for large-scale production of cardioprotective microparticles[J].Mol Cell Cardiol,2010,48(6):1 215-1 224.
    [21]
    Chen TS,Arslan F,Yin Y,et al.Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs[J].Transl Med,2011,9:47.doi: 10.1186/1479-5876-9-47.
    [22]
    Wolfers J,Lozier A,Raposo G,et al.Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming[J].Nat Med,2001,7(3):297-303.
    [23]
    Chen W,Wang J,Shao C,et al.Efficient induction of antitumorT cell immunity by exosomes derived from heatshocked lymphoma cells[J].Eur J Immunol,2006,36(6):1 598-1 607.
    [24]
    Yang Y, Xiu F, Cai Z, et al. Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells[J].Cancer Res Clin Oncol,2007,133(6):389-399.
    [25]
    Chaput N,Schartz NE,AndréF,et al.Exosomes as potent cell-free peptide-based vaccine.II.Exosomes in CpG adjuvants efficiently prime naive Tc1 lymphocytes leading to tumor rejection[J].Immunol,2004,172(4):2 137-2 146.
    [26]
    Dai S, Wei D, Wu Z, et al. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer[J].Mol Ther,2008,16(4):782-790.
    [27]
    Bhatnagar S,Shinagawa K,Castellino FJ,et al.Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo[J].Blood,2007,110(9):3 234-3 244.
    [28]
    Alvarez-Erviti L,Seow YQ,Yin HF,et al.Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes[J].Nat Biotechnol,2011, 29(4):341-345.
    [29]
    Meckes Jr.DG,Shair KH,Marquitz AR,et al.Human tumor virus utilizes exosomes for intercellular communication[J].Proc Natl Acad Sci U S A,2010,107(47):20 370-20 375.
    [30]
    Eldh M,Ekstrom K,Valadi H,et al.Exosomes communicate protective messages during oxidative stress;possible role of exosomal shuttle RNA[J].PLoS ONE,2010,5(12):e15353.
    [31]
    Muller G,Schneider M,Biemer-Daub G,et al.Microvesicles released from rat adipocytes and harboring glycosylphosphatidylinositol-anchored proteins transfer RNA stimulating lipid synthesis[J].Cell Signal,2011,23(7):1 207-1 223.
    [32]
    Akao Y,Iio A,Itoh T,et al.Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages[J].Mol Ther,2011,19(2):395-399.
    [33]
    Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, et al.Unidirectional transfer of microRNA loaded exosomes from T cells to antigen-presenting cells[J].Nat Commun,2011,2:282.
    [34]
    Valadi H,Ekstrom K,Bossios A,et al.Exosomemediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells[J].Nat Cell Biol,2007,9(6):654-659.
    [35]
    Kogure T,Lin WL,Yan IK,et al.Intercellular nanovesiclemediated microRNA transfer:a mechanism of environmental modulation of hepatocellular cancer cell growth[J].Hepatology,2011,54(4):1 237-1 248.
    [36]
    Yang M,Chen J,Su F,et al.Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells[J].Mol Cancer,2011,10:117.doi: 10.1186/1476-4598-10-117.
    [37]
    Walker JD,Maier CL,Pober JS.Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes[J].Immunol,2009,182(3):1 548-1 559.
    [38]
    Zhuang X,Xiang X,Grizzle W,et al.Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain[J].Mol Ther,2011,19(10):1 769-1 779.
    [39]
    Samir EL A,Samira L,Imre M,et al.Exosomes for targeted siRNA delivery across biological barriers[J].Adv Drug Deliv Rev,2013,65(3):391-397.
    [40]
    Sun DM,Zhuang XY,Xiang XY,et al.A novel nanoparticle drug delivery system:the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes[J].Mol Ther,2010,18(9):1 606-1 614.
    [41]
    Illum L.Transport of drugs from the nasal cavity to the central nervous system[J].Eur J Pharm Sci,2000,11(1):1-18.
    [42]
    Sun DM,Zhuang XY,Xiang XY,et al.Exosomes are endogenous nanoparticles that can deliver biological information between cells[J].Adv Drug Deliv Rev,2013,65(3):342-347.
    [43]
    Vyas TK,Shahiwala A,Marathe S,et al.Intranasal drug delivery for brain targeting[J].Curr Drug Deliv,2005,2(2):165-175.
    [44]
    Zhang Y, Luo CL, He BC, et al. Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro:a novel vaccine for renal cell carcinoma[J].Int J Oncol,2010,36(1):133-140.
    [45]
    Bhatnogar S,Schorey JS.Exosomes released from infected macrophages contain Mycobacterium avium glycopeptidolipids and are proinflammatory[J].J Biol Chem,2007,282(35):25 779-25 789.
  • Related Articles

    [1]LIU Mingxuan, GUO Yun, SUN Tao. Drug delivery systems for sensitization of glioblastoma radiotherapy[J]. Journal of China Pharmaceutical University, 2024, 55(5): 624-633. DOI: 10.11665/j.issn.1000-5048.2024050401
    [2]YE Zhenning, WU Zhenghong, ZHANG Huaqing. Research progress of blood-brain barrier crossing strategies and brain-targeted drug delivery mediated by nano-delivery system[J]. Journal of China Pharmaceutical University, 2024, 55(5): 590-602. DOI: 10.11665/j.issn.1000-5048.2024052202
    [3]LUO Xuelian, WU Chengsheng, ZHA Cheng, LIU Sheng. Research progress and prospects of implantable drug delivery systems for postoperative tumor therapy[J]. Journal of China Pharmaceutical University, 2024, 55(4): 538-547. DOI: 10.11665/j.issn.1000-5048.2024040901
    [4]WANG Shihao, LIU Lifeng, DING Yang, LI Suxin. Research progress of pH-responsive drug delivery systems in cancer immunotherapy[J]. Journal of China Pharmaceutical University, 2024, 55(4): 522-529. DOI: 10.11665/j.issn.1000-5048.2024011902
    [5]YU Jiayu, LIN Zezhi, CAO Wei, ZHANG Jianjun, WEI Yuanfeng, GAO Yuan, QIAN Shuai. Research progress of bio-metal organic frameworks in drug delivery system[J]. Journal of China Pharmaceutical University, 2023, 54(1): 23-33. DOI: 10.11665/j.issn.1000-5048.20221111003
    [6]LI Haoxian, LIN Huaqing, CHEN Jingwen, WANG Liyuan. Research progress of carbon nanomaterials in cancer drug delivery[J]. Journal of China Pharmaceutical University, 2019, 50(1): 100-106. DOI: 10.11665/j.issn.1000-5048.20190114
    [7]FAN Qianqian, XING Lei, QIAO Jianbin, ZHANG Chenglu, JIANG Hulin. Advances in drug delivery systems for the treatment of liver fibrosis[J]. Journal of China Pharmaceutical University, 2018, 49(3): 263-271. DOI: 10.11665/j.issn.1000-5048.20180302
    [8]HE Wei, QI Haixia, DONG Lei, ZHANG Junfeng. Research advances in drug delivery system targeting immune system[J]. Journal of China Pharmaceutical University, 2015, 46(5): 513-520. DOI: 10.11665/j.issn.1000-5048.20150501
    [9]WU Qu, HUO Meirong, ZHOU Jianping. Advances on novel drug delivery system[J]. Journal of China Pharmaceutical University, 2013, 44(2): 97-104. DOI: 10.11665/j.issn.1000-5048.20130201
    [10]TANG Yue, KE Xue. Advances of mesoporous silica nanoparticles as drug delivery system[J]. Journal of China Pharmaceutical University, 2012, 43(6): 567-572.

Catalog

    Article views (1416) PDF downloads (3116) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return