• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
SHEN Lingling, CHEN Jinlong, SU Mengxiang, YAN Fang, LI Bo, DI Bin. Synthesis and characterization of folic acid modified mesoporous silica nanoparticles and its loading performance for realgar[J]. Journal of China Pharmaceutical University, 2014, 45(3): 314-319. DOI: 10.11665/j.issn.1000-5048.20140311
Citation: SHEN Lingling, CHEN Jinlong, SU Mengxiang, YAN Fang, LI Bo, DI Bin. Synthesis and characterization of folic acid modified mesoporous silica nanoparticles and its loading performance for realgar[J]. Journal of China Pharmaceutical University, 2014, 45(3): 314-319. DOI: 10.11665/j.issn.1000-5048.20140311

Synthesis and characterization of folic acid modified mesoporous silica nanoparticles and its loading performance for realgar

More Information
  • Mesoporous silica nanoparticles(MSN)were synthesized under alkaline conditions using tetraethoxysilane(TEOS)as silica source, hexadecyl trimethyl ammonium bromide(CTAB)as template agent, ethanol as co-solvent and triethanolamine as chelating agent. Ammonia propyl and folic acid(FA)were then modified on the surface of MSN in two consecutive steps. The morphology and structure were characterized, and the loading amount of realgar was determined by atomic fluorescence spectrometry. Results showed that the MSN had large specific surface area(973 m2/g)and pore volume(1. 01 cm3/g), narrow pore size distribution, uniform particle size(about 90 nm)and well-dispersed spherical morphology. The assayed loading ratio of realgar in FA- modified MSN reached the maximum(2. 52%)in 0. 5 h. Hence, it was shown that the MSN-NH-FA has good morphology and favorable structure which is suitable as a drug carrier and hold potential in the application.
  • [1]
    Liu R,Pu DM.The research progress of realgar[J].Lishizhen Med Mater Med Res(时珍国医国药),2007,18(4):982-984.
    [2]
    Wu JZ,Shao YB,Liu J L,et al.The medicinal use of realgar(As4S4)and its recent development as an anticancer agent[J].J Ethnopharmacol,2011,135(3):595-602.
    [3]
    Ping DZ.Study on the preparation and characteristics of the nanometer powder of Realgar,Margarita and Rhizoma coptidis(珍珠、雄黄和黄连纳米粉体的制备与特性研究)[D].Beijing:Beijing University of Traditional Chinese Medicine,2004.
    [4]
    Zhao WZ,Lu X,Yuan Y,et al.Effect of size and processing method on the cytotoxicity of realgar nanoparticles in cancer cell lines[J].Int J Nanomed,2011,6:1 569-1 577.
    [5]
    Yang XL,Xu HB,Ye HQ,et al.Nanometer realgar solid dispersion and its preparation method:CN,1478486[P].2004-03-03.
    [6]
    Shen XC,Liang H,Chen Y,et al.Method for preparing nanometer realgar gel and nanometer realgar with biomacromolecule template to regulate shape and particle thereof:CN,100374463 C[P].2008-03-12.
    [7]
    Morelli C,Maris P,Sisci D,et al.PEG-templated mesoporous silica nanoparticles exclusively target cancer cells[J].Nanoscale,2011,3(8):3 198-3 207.
    [8]
    Tang FQ,Li LL,Chen D.Mesoporous silica nanoparticles:synthesis,biocompatibility and drug delivery[J].Adv Mater,2012,24(12):1 504-1 534.
    [9]
    Gullotti E,Yeo Y.Extracellularly activated nanocarriers:a new paradigm of tumor targeted drug delivery[J].Mol Pharmaceut,2009,6(4):1 041-1 051.
    [10]
    Möller K,Kobler J,Bein T.Colloidal suspensions of nanometer-sized mesoporous silica[J].Adv Funct Mater,2007,17(4):605-612.
    [11]
    Wang JZ,Lin M,Zhang TY,et al.Arsenic(II)sulfide quantum dots prepared by a wet process from its bulk[J].J Am Chem Soc,2008,130(35):11 596-11 597.
    [12]
    Huang XL,Teng X,Chen D,et al.The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function[J].Biomaterials,2010,31(3):438-448.
    [13]
    Abarkan I,Doussineau T,Smaïhi M.Tailored macro/microstructural properties of colloidal silica nanoparticles via microemulsion preparation[J].Polyhedron,2006,25(8):1 763-1 770.
  • Related Articles

    [1]ZHAO Di, LI Jingjing, ZHANG Kai, QIN Chao, YANG Lei, YIN Lifang. Preparation and in vitro characterization of remdesivir-loaded liposomes for inhalation[J]. Journal of China Pharmaceutical University, 2021, 52(5): 547-554. DOI: 10.11665/j.issn.1000-5048.20210506
    [2]CHEN Yangjian, CHEN Xinqi, ZHENG Xiangyun, SONG Xiaoda. Research on PEGylated uricase by periodate oxidation and reductive- amination[J]. Journal of China Pharmaceutical University, 2015, 46(3): 364-370. DOI: 10.11665/j.issn.1000-5048.20150318
    [3]XU Lei, TIAN Ji-xin, SONG Rui, LIU Guo-qiang, TIAN Yuan, ZHANG Zun-jian. LC-MS/MS determination and comparison of saikosaponin a,b2,c,d in crude and processed radix bupleuri by vinegar[J]. Journal of China Pharmaceutical University, 2012, 43(4): 334-340.
    [4]ZHAO Li-gang, YANG Qing-min, YANG Guang-li, WANG Dong-hai, YAN Shou-sheng, ZHANG Hui, WANG Jing-yi. Encapsulation efficiency and efficacy of vinorelbine tartrate long-circulating liposomes[J]. Journal of China Pharmaceutical University, 2010, 41(6): 508-512.
    [5]Preparation of aFGF liposomes and their release behavior in vitro[J]. Journal of China Pharmaceutical University, 2010, 41(3): 248-252.
    [6]Preparation of Azithromycin Liposome and Its Entrapment Efficiency Determination[J]. Journal of China Pharmaceutical University, 2004, (6): 18-21.
    [7]Effects of Chitosan-EDTA Conjugates on Insulin Nano-liposomes[J]. Journal of China Pharmaceutical University, 2004, (5): 31-37.
    [9]Determination of Three Bufadienolides in the Liposome-Ch''an Su by RP-HPLC[J]. Journal of China Pharmaceutical University, 1993, (2): 116-118.
    [10]QUANTITATION OF LIPOSOME CONTAINING HARRINGTONINE AND OF HARRINGTONINE IN TISSUES OF RAT BY HPLC[J]. Journal of China Pharmaceutical University, 1989, (2): 77-81.

Catalog

    Article views (1387) PDF downloads (2213) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return