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QIAO Hongzhi, SUN Minjie, XIE Ying, PING Qineng, ZONG Li. Preparation and characterization of hydrocaffeoylchitosan-copper-doxorubicin ternary coordination supermolecule for renal targeting[J]. Journal of China Pharmaceutical University, 2014, 45(4): 420-426. DOI: 10.11665/j.issn.1000-5048.20140407
Citation: QIAO Hongzhi, SUN Minjie, XIE Ying, PING Qineng, ZONG Li. Preparation and characterization of hydrocaffeoylchitosan-copper-doxorubicin ternary coordination supermolecule for renal targeting[J]. Journal of China Pharmaceutical University, 2014, 45(4): 420-426. DOI: 10.11665/j.issn.1000-5048.20140407
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Preparation and characterization of hydrocaffeoylchitosan-copper-doxorubicin ternary coordination supermolecule for renal targeting

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  • Hydrocaffeoylchitosan(HCAC)was synthesized and characterized with 15. 6% substitution degree of hydrocaffeic acid. Ternary coordination supermolecule HCAC-Cu-Dox was subsequently fabricated through the solvent-induced precipitation method in the presence of HCAC, Cu(NO3)2 ·3H2O and Dox. The contents of Dox and Cu were(7. 8±0. 3)% and(5. 2±0. 2)% determined by high-performance liquid chromatography(HPLC)and inductively coupled plasma-atomic emission spectrometry(ICP-AES), respectively. The supermolecule was in spherical shape with an average particle size of(68. 7±3. 9)nm observed by TEM. The binding constant of supermolecule was measured, and thermodynamic property was evaluated, indicating that Dox installed in supermolecule existed in amorphous or molecular state. Besides, in vitro release profile indicated that supermolecule possessed satisfactory stable in physiological conditions, and only 13. 5% of Dox were detected in 24 h. Furthermore, the near-infrared fluorescence(NIRF)imaging showed that the supermolecule could be specifically delivered to kidney after intravenous injection, while hardly accumulated in other organs. Cytotoxicity assay by MTT method showed that A498 cells were significantly inhibited after incubation with HCAC-Cu-Dox. In conclusion, HCAC-Cu-Dox ternary coordination supermolecule has potential for renal targeting and treatment.
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  • [1]
    Dolman ME,Harmsen S,Storm G,et al.Drug targeting to the kidney:advances in the active targeting of therapeutics to proximal tubular cells[J].Adv Drug Deliv Rev,2010,62(14):1 344-1 357.
    [2]
    Suzuki K,Susaki H,Okuno S,et al.Renal drug targeting using a vector ″alkylglycoside″[J].J Pharmacol Exp Ther,1999,288(1):57-64.
    [3]
    Zhang Z,Zheng Q,Han J,et al.The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells[J].Biomaterials,2009,30(7):1 372-1 381.
    [4]
    Prakash J,van Loenen-Weemaes AM,Haas M,et al.Renal-selective delivery and angiotensin-converting enzyme inhibition by subcutaneously administered captopril-lysozyme[J].Drug Metab Dispos,2005,33(5):683-688.
    [5]
    Yuan ZX,Zhang ZR,Zhu D,et al.Specific renal uptake of randomly 50% N-acetylated low molecular weight chitosan[J].Mol Pharm,2009,6(1):305-314.
    [6]
    Uehara T,Ishii D,Uemura T,et al.gamma-Glutamyl PAMAM dendrimer as versatile precursor for dendrimer-based targeting devices[J].Bioconjug Chem,2010,21(1):175-181.
    [7]
    Kamada H,Tsutsumi Y,Sato-Kamada K,et al.Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride)co-polymer and its application for renal drug targeting[J].Nat Biotechnol,2003,21(4):399-404.
    [8]
    Schechter B, Arnon R, Colas C, et al. Renal accumulation of streptavidin:potential use for targeted therapy to the kidney[J].Kidney Int,1995,47(5):1 327-1 335.
    [9]
    Xing L,Zheng H,Cao Y,et al.Coordination polymer coated mesoporous silica nanoparticles for pH-responsive drug release[J].Adv Mater,2012,24(48):6 433-6 437.
    [10]
    Ryu JH,Lee Y,Kong WH,et al.Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials[J].Biomacromolecules,2011,12(7):2 653-2 659.
    [11]
    Niu J,Su Z,Xiao Y,et al.Octreotide-modified and pH-triggering polymeric micelles loaded with doxorubicin for tumor targeting delivery[J].Eur J Pharm Sci,2012,45(1/2):216-226.
    [12]
    Deshayes S,Cabral H,Ishii T,et al.Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors[J].J Am Chem Soc,2013,135(41):15 501-15 507.
    [13]
    Xing L,Zheng H,Che S.A pH-responsive cleavage route based on a metal-organic coordination bond[J].Chemistry,2011,17(26):7 271-7 275.
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