Synthesis and biological activities of novel hybrid compounds based on piperazines and acetophenones

MAO Zewei; WAN Chunping; ZHENG Xi; JIANG Yuan; RAO Gaoxiong

doi:10.11665/j.issn.1000-5048.20140502

Journal of China Pharmaceutical University > 2014 > 45(5): 517-521. > DOI: 10.11665/j.issn.1000-5048.20140502

MAO Zewei, WAN Chunping, ZHENG Xi, JIANG Yuan, RAO Gaoxiong. Synthesis and biological activities of novel hybrid compounds based on piperazines and acetophenones[J]. Journal of China Pharmaceutical University, 2014, 45(5): 517-521. DOI: 10.11665/j.issn.1000-5048.20140502

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Synthesis and biological activities of novel hybrid compounds based on piperazines and acetophenones

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A series of novel hybrid derivatives based on acetophenones and piperazines were synthesized; and the structures were characterized by ¹H NMR and ¹³C NMR. The result of in vitro assays indicated that compound Ⅱ1 was most potent against 3 strains of human tumor cell lines(HeLa, A549 and H1975), with moderate antibacterial activity against Pseudomonas aeruginosa(MIC=8. 33 μg/mL)and Escherichia coli(MIC=1. 04 μg/mL). Compound Ⅱ1 could be a lead compound for further structural modifications and biological evaluation.
- piperazine,
- acetophenone,
- derivatives,
- synthesis,
- biological activity

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