Synthesis and biological activities of novel hybrid compounds based on piperazines and acetophenones

A series of novel hybrid derivatives based on acetophenones and piperazines were synthesized; and the structures were characterized by ¹H NMR and ¹³C NMR. The result of in vitro assays indicated that compound Ⅱ1 was most potent against 3 strains of human tumor cell lines(HeLa, A549 and H1975), with moderate antibacterial activity against Pseudomonas aeruginosa(MIC=8. 33 μg/mL)and Escherichia coli(MIC=1. 04 μg/mL). Compound Ⅱ1 could be a lead compound for further structural modifications and biological evaluation.