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YANG Yang, QIAN Jie, LI Li, DI Bin. Preparation and characterization of a novel HPLC stationary phase binaphthyl functionalized mesoporous silica[J]. Journal of China Pharmaceutical University, 2014, 45(5): 557-562. DOI: 10.11665/j.issn.1000-5048.20140509
Citation: YANG Yang, QIAN Jie, LI Li, DI Bin. Preparation and characterization of a novel HPLC stationary phase binaphthyl functionalized mesoporous silica[J]. Journal of China Pharmaceutical University, 2014, 45(5): 557-562. DOI: 10.11665/j.issn.1000-5048.20140509
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Preparation and characterization of a novel HPLC stationary phase binaphthyl functionalized mesoporous silica

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  • In this study, a novel silica source named M-bionl was synthesized by(3-isocyanatopropyl)-triethoxysilane(ICPTES)and R-(+)-1, 1′-bi-2-naphthol. A new mesoporous silica was first obtained by M-bionl and Bis(triethoxysilyl)ethane(BTSE)as co-silica source, hexadecyl trimethyl ammonium bromide(CTAB)and PEO-PPO-PEO(P123)as co-template in acid condition. The diameter of particles was 3-5 μm with mean pore size of 5 nm. Then the separation capacity of the mesoporous silicas was tested, with excellent mechanical strength and complete separation of 5 kinds of binaphthyl compounds being achieved within 15 min, which indicated a promising application of these mesoporous silicas in HPLC and their separation performance was superior to commercial silica for binaphyhyl compounds.
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