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SONG Li, HE Shengjiang, ZHANG Xiantao. Preparation and in vitro characterization of ginkgolide B-loaded mPEG-PLA polymeric micelles[J]. Journal of China Pharmaceutical University, 2014, 45(6): 681-683. DOI: 10.11665/j.issn.1000-5048.20140611
Citation: SONG Li, HE Shengjiang, ZHANG Xiantao. Preparation and in vitro characterization of ginkgolide B-loaded mPEG-PLA polymeric micelles[J]. Journal of China Pharmaceutical University, 2014, 45(6): 681-683. DOI: 10.11665/j.issn.1000-5048.20140611
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Preparation and in vitro characterization of ginkgolide B-loaded mPEG-PLA polymeric micelles

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  • Ginkgolide B-loaded mPEG-PLA polymeric micelles(GB-mPEG-PLA)was prepared by emulsification- solvent diffusion method. The drug loading, encapsulation efficiency, average particle size and size distribution of GB-mPEG-PLA were evaluated. Moreover, the in vitro release characteristics of GB-mPEG-PLA were investigated by dialysis. The average particle size of GB-mPEG-PLA was 74. 5 nm, the drug loading and encapsulation efficiency were 7. 5% and 82. 2%, respectively. SEM image showed GB-mPEG-PLA was spherical in shape. In addition, the release profile of ginkgolide B from GB-mPEG-PLA exhibited an extended-release pattern. Therefore, GB-mPEG-PLA can be a promising nano-sized drug delivery system in the future.
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    • References (4)
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