Preparation and in vitro characterization of ginkgolide B-loaded mPEG-PLA polymeric micelles

Ginkgolide B-loaded mPEG-PLA polymeric micelles(GB-mPEG-PLA)was prepared by emulsification- solvent diffusion method. The drug loading, encapsulation efficiency, average particle size and size distribution of GB-mPEG-PLA were evaluated. Moreover, the in vitro release characteristics of GB-mPEG-PLA were investigated by dialysis. The average particle size of GB-mPEG-PLA was 74. 5 nm, the drug loading and encapsulation efficiency were 7. 5% and 82. 2%, respectively. SEM image showed GB-mPEG-PLA was spherical in shape. In addition, the release profile of ginkgolide B from GB-mPEG-PLA exhibited an extended-release pattern. Therefore, GB-mPEG-PLA can be a promising nano-sized drug delivery system in the future.