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HAO Kun, YU Dan, WANG Guangji. Pharmacokinetic translational research from bench to bedside[J]. Journal of China Pharmaceutical University, 2015, 46(1): 50-57. DOI: 10.11665/j.issn.1000-5048.20150105
Citation: HAO Kun, YU Dan, WANG Guangji. Pharmacokinetic translational research from bench to bedside[J]. Journal of China Pharmaceutical University, 2015, 46(1): 50-57. DOI: 10.11665/j.issn.1000-5048.20150105
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Pharmacokinetic translational research from bench to bedside

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    • Abstract
  • The pharmacokinetic translation from bench to bedside has been an important component in translational research. Based on non-clinical pharmacokinetic research results, scale factor allometric model and physiology- based pharmacokinetic model were used to investigate the translational method of pharmacokinetic parameters from quantitative pharmacology perspective. The method includes the reasonable extrapolation of translation for inter-species and analysis of in vivo-in vitro differences. The pharmacokinetic translation model from bench to bedside will help to optimize clinical administration into simulation study.
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