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MAO Zewei, WAN Chunping, JIANG Yuan, GUO Wenlian, RAO Gaoxiong. Synthesis and anti-tumor activity in vitro of N-hetercycle substituted benzofuran derivatives[J]. Journal of China Pharmaceutical University, 2015, 46(1): 58-61. DOI: 10.11665/j.issn.1000-5048.20150106
Citation: MAO Zewei, WAN Chunping, JIANG Yuan, GUO Wenlian, RAO Gaoxiong. Synthesis and anti-tumor activity in vitro of N-hetercycle substituted benzofuran derivatives[J]. Journal of China Pharmaceutical University, 2015, 46(1): 58-61. DOI: 10.11665/j.issn.1000-5048.20150106
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Synthesis and anti-tumor activity in vitro of N-hetercycle substituted benzofuran derivatives

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  • To discover the novel compounds with biological activity, N-hetercycle substituted derivatives were synthesized based on the structure of benzofuran. A series of novel N-hetercycle substituted benzofuran derivatives( 2a - 2j )were synthesized by the reaction of 2-(4′-florobenzoyl)benzofuran with N-heterocyclic compounds. And the structures were characterized by 1H NMR, 13C NMR and HRMS. Their anti-tumor activities were studied in vitro against a panel of human tumor cell lines(HeLa, A549 and H1975)by the MTT assay. The results indicate that compounds 2a , 2f and 2j are the most potent within this series of compounds against human tumor cell lines, showing that they are promising lead compounds for further structural modifications and biological evaluation.
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