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LIU Chao, ZHONG Xing, XI Yanqiong, TANG Yinxia, JIANG Li, WANG Fujun, PU Tong, ZENG Su. Determination of the related substances of tenofovir by RP-HPLC[J]. Journal of China Pharmaceutical University, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
Citation: LIU Chao, ZHONG Xing, XI Yanqiong, TANG Yinxia, JIANG Li, WANG Fujun, PU Tong, ZENG Su. Determination of the related substances of tenofovir by RP-HPLC[J]. Journal of China Pharmaceutical University, 2015, 46(1): 78-80. DOI: 10.11665/j.issn.1000-5048.20150110
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Determination of the related substances of tenofovir by RP-HPLC

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  • To investigate the related substances of tenofovir, 3 related substances were synthesized. RP-HPLC analytical method was developed using Agilent ZORBAX SB-C18 column. The mobile phase composed of methanol and 0. 02 mol/L potassium dihydrogen phosphate. Linear gradient elution was used and the detection wavelength was 260 nm. 3 impurities were found in tenofovir. The established method was accurate and reproducible, and it can be applied for the related substances test in tenofovir.
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    • References (4)
  • [1]
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    Mansoor LE,Karim QA,Werner L,et al.Impact of an adherence intervention on the effectiveness of tenofovir gel in the CAPRISA 004 trial[J].AIDS Behav,2014,18(5):841-848.
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