Inhibitory effect of diarylheptanoids from<i> Alpinia oxyphylla</i> on angiogenesis

GAO Xiaoping; CHEN Lixiao; YIN Zhiqi; JIANG Linlin; LIN Qinghua; HE Mingfang

doi:10.11665/j.issn.1000-5048.20150112

Journal of China Pharmaceutical University > 2015 > 46(1): 85-88. > DOI: 10.11665/j.issn.1000-5048.20150112

GAO Xiaoping, CHEN Lixiao, YIN Zhiqi, JIANG Linlin, LIN Qinghua, HE Mingfang. Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis[J]. Journal of China Pharmaceutical University, 2015, 46(1): 85-88. DOI: 10.11665/j.issn.1000-5048.20150112

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Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis

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This study investigated the anti-angiogenic activities of two diarylheptanoids, together with a structure analogue, curcumin. The activity and toxicity of these three compounds were compared using transgenic zebrafish as in vivo model and human umbilical vein endothelial cell(HUVEC)as in vitro model. Anti-angiogenic index(AI)was used as the ratio between LC₅₀ and EC₅₀. The results suggested that in both in vitro and in vivo assay, curcumin exerted the most potent anti-angiogenic effect but with lowest toxicity among these compounds; Yakuchinone A was the second potent; Yakuchinone B has the lowest activity but with the highest toxicity in all three compounds. Taken together, curcumin was the best angiogenic inhibitor in these three diarylheptanoids.
- angiogenesis,
- zebrafish,
- HUVEC,
- curcumin,
- diarylheptanoid,
- Yakuchinone A,
- Yakuchinone B

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Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis

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