• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
GAO Xiaoping, CHEN Lixiao, YIN Zhiqi, JIANG Linlin, LIN Qinghua, HE Mingfang. Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis[J]. Journal of China Pharmaceutical University, 2015, 46(1): 85-88. DOI: 10.11665/j.issn.1000-5048.20150112
Citation: GAO Xiaoping, CHEN Lixiao, YIN Zhiqi, JIANG Linlin, LIN Qinghua, HE Mingfang. Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis[J]. Journal of China Pharmaceutical University, 2015, 46(1): 85-88. DOI: 10.11665/j.issn.1000-5048.20150112
shu

Inhibitory effect of diarylheptanoids from Alpinia oxyphylla on angiogenesis

More Information
    Graphical Abstract
    • Abstract
  • This study investigated the anti-angiogenic activities of two diarylheptanoids, together with a structure analogue, curcumin. The activity and toxicity of these three compounds were compared using transgenic zebrafish as in vivo model and human umbilical vein endothelial cell(HUVEC)as in vitro model. Anti-angiogenic index(AI)was used as the ratio between LC50 and EC50. The results suggested that in both in vitro and in vivo assay, curcumin exerted the most potent anti-angiogenic effect but with lowest toxicity among these compounds; Yakuchinone A was the second potent; Yakuchinone B has the lowest activity but with the highest toxicity in all three compounds. Taken together, curcumin was the best angiogenic inhibitor in these three diarylheptanoids.
    • FullText(HTML)
    • References (12)
  • [1]
    Finley SD, Chu LH, Popel AS. Computational systems biology approaches to anti-angiogenic cancer therapeutics[J].Drug Discov Today,2014.doi: 10.1016/j.drudis.2014.09.026.
    [2]
    Folkman J.Tumor angiogenesis:therapeutic implications[J].N Engl J Med,1971,285:1182-1186.
    [3]
    He MF,Huang YH,Wu LW,et al.Triptolide functions as a potent angiogenesis inhibitor[J].Int J Cancer,2010,126(1):266-278.
    [4]
    He ZH,He MF,Ma SC,et al.Anti-angiogenic effects of rhubarb and its anthraquinone derivatives[J].J Ethnopharmacol,2009,121(2):313-317.
    [5]
    Zhao D, Qin C, Fan X, et al. Inhibitory effects of quercetin on angiogenesis in larval zebrafish and human umbilical vein endothelial cells[J].Eur J Pharmacol,2014,723:360-367.
    [6]
    Alex D, Lam IK, Lin Z, et al. Indirubin shows anti-angiogenic activity in an in vivo zebrafish model and an in vitro HUVEC model[J].J Ethnopharmacol,2010,131(2):242-247.
    [7]
    Chun KS,Park KK,Lee J,et al.Inhibition of mouse skin tumor promotion by anti-inflammatory diaryheptanoids derived from Alpinia oxyphylla Miquel(Zingiberaceae)[J].Oncol Res,2002,13(1):37-45.
    [8]
    He ZH,Ge W,Yue GG,et al.Anti-angiogenic effects of the fruit of Alpinia oxyphylla[J].J Ethnopharmacol,2010,132(2):443-449.
    [9]
    Shoji N,Umeyama A,Takemoto T,et al.Isolation of a cardiotonic principle from Alpinia oxyphylla[J].Planta Med,1984,50(2):186-187.
    [10]
    Wang CM,Jing LJ,Wei YJ,et al.Evaluation of antiosteoporotic activity for micro-amount asperosaponins V and VI by on the osteoporosis model using zebrafish[J].J China Pharm Univ(中国药科大学学报),2014,45(1):88-91.
    [11]
    Liang D,Chang JR,Chin AJ,et al.The role of vascular endothelial growth factor(VEGF)in vasculogenesis,angiogenesis,and hematopoiesis in zebrafish development[J].Mech Dev,2001,108:29-43.
    [12]
    Pham VN, Roman BL, Weinstein BM, et al. Isolation and expression analysis of three zebrafish angiopoietin genes[J].Dev Dyn,2001,221(4):470-474.
    • Related Articles

  • Related Articles

    [1]DENG Zhen, HUANG Wei, WANG Xiaoqin. Effects of Pseudomonas aeruginosa PmrB△Leu172 mutation on polymyxin B resistance[J]. Journal of China Pharmaceutical University, 2024, 55(6): 809-815. DOI: 10.11665/j.issn.1000-5048.2023121001
    [2]WANG Xin, ZHAO Xiaomei, ZHANG Pingping, JI Xia, HU Guoqiang. Synthesis and antitumor activity of 1, 2-benzothiazines imidazolo ［1, 2-b］［1, 3, 4］ triazazole derivatives[J]. Journal of China Pharmaceutical University, 2019, 50(5): 540-543. DOI: 10.11665/j.issn.1000-5048.20190505
    [3]CAO Sufen, XIE Qin, CHEN Yi, DUAN Wenhu. Synthesis and antiproliferative activities of 5H-benzo［b］carbazole-6, 11-diones[J]. Journal of China Pharmaceutical University, 2017, 48(2): 157-166. DOI: 10.11665/j.issn.1000-5048.20170205
    [4]SONG Li, HE Shengjiang, ZHANG Xiantao. Preparation and in vitro characterization of ginkgolide B-loaded mPEG-PLA polymeric micelles[J]. Journal of China Pharmaceutical University, 2014, 45(6): 681-683. DOI: 10.11665/j.issn.1000-5048.20140611
    [5]DONG Gaochao, ZHOU Xiang, TANG Weifang, LU Tao. Advances in the research and development of B-Raf inhibitors[J]. Journal of China Pharmaceutical University, 2014, 45(1): 1-9. DOI: 10.11665/j.issn.1000-5048.20140101
    [6]MU Yanan, YANG Jin. Determination of epothilone B in human blood by LC-MS/MS and its application in phase I pharmacokinetics study[J]. Journal of China Pharmaceutical University, 2013, 44(1): 89-92. DOI: 10.11665/j.issn.1000-5048.20130115
    [7]SHAO Jing-ping, ZHANG Shan-fei, CHEN Yuan-cheng, YANG Wen-liang, LIU Xiao-quan. Cellular uptake characteristics of salvianolic acid B in myocardial cells and blood vessel endothelial cells[J]. Journal of China Pharmaceutical University, 2009, 40(3): 263-268.
    [8]YU Dan, CHAI Jian-guo, CAO Yan-guang, CHEN Yuan-cheng, LIU Xiao-quan. Effects of salvianolic acid B on the pharmacokinetics of danshensu in Danshen injection in rats[J]. Journal of China Pharmaceutical University, 2009, 40(3): 258-262.
    [9]Determination of Nicotinamide and Vitamin B_6 in Compound Vitamin B Injection by HPLC[J]. Journal of China Pharmaceutical University, 2002, (2): 83-85.
    [10]HPLC Analysis of Jolkinolide B in the Roots of EuphorbiaPlants[J]. Journal of China Pharmaceutical University, 1994, (6): 332-334.

Catalog

    Get Citation
    PDF
    XML
    Article views (1418) PDF downloads (2315) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：292717

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return