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REN Yi, SU Mei, ZHENG Jing, QIN Yinlin, CHEN Tao, JI Hui. Protective effects of Naomaili granules on cerebral ischemia-reperfusion in rats and its mechanism[J]. Journal of China Pharmaceutical University, 2015, 46(1): 100-104. DOI: 10.11665/j.issn.1000-5048.20150115
Citation: REN Yi, SU Mei, ZHENG Jing, QIN Yinlin, CHEN Tao, JI Hui. Protective effects of Naomaili granules on cerebral ischemia-reperfusion in rats and its mechanism[J]. Journal of China Pharmaceutical University, 2015, 46(1): 100-104. DOI: 10.11665/j.issn.1000-5048.20150115
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Protective effects of Naomaili granules on cerebral ischemia-reperfusion in rats and its mechanism

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  • The objective of the study was to determine the potential effects of Naomaili granules on rats subjected to ischemia and reperfusion. With the exception of animals in sham group, all animals in treatment groups were subjected to ischemia and reperfusion by middle cerebral artery occlusion(MCAO)with thread technique. The ability of anti-cerebral ischemia, relieving cerebral edema and antioxidation was evaluated by the measurement of neurological deficit score, ratios of infarction area, brain water content, histopathological score and biochemical indexes related to oxidative stress in brain tissue. Significantly reduction of infarction area, histopathological score, contents of H2O2 and MDA were observed at 6 g/kg and 3 g/kg Naomaili granules compared to animals in the model group; the capacity of inhibition of superoxide anion radical(O-·2)and hydroxyl radial( ·OH)were also found to have increased. Additionally, Naomaili granules(6 g/kg)improved neurological function, reduced brain water content, and increased the level of GSH, GSH-Px and SOD compared with model group. The result suggested that Naomaili granules exhibited obvious protection against cerebral ischemia and reperfusion-induced injury due to its antioxidating effect.
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  • [1]
    Tao T,Liu Y,Zhang J,et al.Therapeutic hypercapnia improves functional recovery and attenuates injury via antiapoptotic mechanisms in a rat focal cerebral ischemia/reperfusion model[J].Brain Res,2013,1533:52-62.
    [2]
    Zhang L,Chang BB,Cao WW,et al.Effect of danshensu on myocardial energy metabolism in isolated ischemia reperfusion rat hearts[J].J China Pharm Univ(中国药科大学学报),2010,41(3):278-282.
    [3]
    Shang YH,Xu XY.Advance of experimental studies on protective effect of traditional Chinese medicines and their extracts on cerebral ischemia[J].China J Chin Mater Med(中国中药杂志),2013,38(8):1109-1109.
    [4]
    Shi XR,Hong ZY,Liu HR.Neuroprotective effects of SCM198 on 6-hydroxydopamine-induced behavioral deficit in rats and cytotoxicity in neuronal SH-SY5Y cells[J].Neurochem Int,2011,58(8):851-860.
    [5]
    Wen DZ,Qu JB,Shi Z,et al.Effect of sanchi saponin Rh1 against aging of astrocyte in D-galactose induced aging mice model[J].Chin J Neuroanatomy(神经解剖学杂志),2005,21(6):667-670.
    [6]
    Zhang XH,Xu XX,Wang NQ.Progress of studies on protective mechanism of Radix Astragali in vascular endothelial cell[J].Chin Pharm J(中国药学杂志),2013,48(18):1526-1530.
    [7]
    Liu SX,Li YM,Fang WR.Protective effect of sodium tanshinone B on focal cerebral ischemia-reperfusion injury in rats[J].J China Pharm Univ(中国药科大学学报),2008,39(4):338-342.
    [8]
    Chung JY,Kim MW,Bang MS,et al.Increased expression of neurotrophin 4 following focal cerebral ischemia in adult rat brain with treadmill exercise[J].PLoS One,2013,8(3):e52461.
    [9]
    Wang JP,Yang ZT,Liu C,et al.l-Carnosine inhibits neuronal cell apoptosis through signal transducer and activator of transcription 3 signaling pathway after acute focal cerebral ischemia[J].Brain Res, 2013,1507:125-133.
    [10]
    Wang T,Li Y,Wang Y,et al.Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice[J].PLoS One, 2014,9(3):e90780.
    [11]
    Wu J,Chen J,Guo H,et al.Effects of high-pressure oxygen therapy on brain tissue water content and AQP4 expression in rabbits with cerebral hemorrhage[J].Cell Biochem Biophys,2014,70(3):1579-1584.
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