Roles of Moesin in tumor progression

ZHANG Jinghui; WANG Yajing; HU Rong

doi:10.11665/j.issn.1000-5048.20150319

Journal of China Pharmaceutical University > 2015 > 46(3): 371-375. > DOI: 10.11665/j.issn.1000-5048.20150319

ZHANG Jinghui, WANG Yajing, HU Rong. Roles of Moesin in tumor progression[J]. Journal of China Pharmaceutical University, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319

Citation:

ZHANG Jinghui, WANG Yajing, HU Rong. Roles of Moesin in tumor progression[J]. Journal of China Pharmaceutical University, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319

Citation:

ZHANG Jinghui, WANG Yajing, HU Rong. Roles of Moesin in tumor progression[J]. Journal of China Pharmaceutical University, 2015, 46(3): 371-375. DOI: 10.11665/j.issn.1000-5048.20150319

Roles of Moesin in tumor progression

More Information

Graphical Abstract

Abstract

Abstract

Moesin is a component of ERM(Ezrin/Radixin/Moesin)family proteins linking cell membrane proteins with cytoskeleton. It is involved in cell morphological change and the maintaining of cell cortex and is also involved in cell adhesion, migration and polarization by regulating the signal transduction pathways. Moesin plays a vital role in several aspects of tumor initiation and progression through its regulation on cytoskeleton and signal transduction pathways. This article reviews the close relation between Moesin and its phosphorylated form with the higher level of malignancy and poor prognosis through clinic data analysis. Furthermore, the role and mechanism of Moesin on tumor migration, EMT and tumor proliferation are presented. Drug research and development based on the target of Moesin are also concluded.
- Moesin,
- tumor progression,
- target,
- signal transduction,
- cytoskeleton,
- CD44/Moesin inhibitor

FullText(HTML)

References (26)

References

[1]	Sato N,Funayama N,Nagafuchi A,et al.A gene family consisting of ezrin,radixin and moesin.Its specific localization at actin filament/plasma membrane association sites[J].J Cell Sci,1992,103(1):131-143.
[2]	Bretscher A,Edwards K,Fehon RG.ERM proteins and merlin:integrators at the cell cortex[J].Nat Rev Mol Cell Biol,2002,3(8):586-599.
[3]	Fehon RG,Mcclatchey AI,Bretscher A.Organizing the cell cortex:the role of ERM proteins[J].Nat Rev Mol Cell Biol,2010,11(4):276-287.
[4]	Lan M, Kojima T, Murata M, et al. Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line[J].Exp Cell Res,2006,312(2):111-120.
[5]	Baumgartner M, Sillman AL, Blackwood EM, et al. The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors[J].Proc Natl Acad Sci U S A,2006,103(36):13391-13396.
[6]	Takeuchi K,Sato N,Kasahara H,et al.Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members[J].J Cell Biol,1994,125(6):1371-1384.
[7]	Neisch AL,Fehon RG.Ezrin,radixin and moesin:key regulators of membrane-cortex interactions and signaling[J].Curr Opin Cell Biol,2011,23(4):377-382.
[8]	Jung Y,Mccarty JH.Band 4.1 proteins regulate integrin-dependent cell spreading[J].Biochem Biophys Res Commun,2012,426(4):578-584.
[9]	Lin L. Studies on expressions of Ezrin and Moesin in cervical squamous cell carcinoma and Siha cell(Ezrin和Moesin在宫颈鳞癌组织和SiHa细胞表达的研究)[D].Fuzhou:Fujian Mdeical University,2008.
[10]	Zhou Q,Deng T.Expression of Moesin and Endogolin(CD₁₀₅)in squamous carcinoma and its clinic significance[J].J Prac Obst Gyne(实用妇产科杂志),2011,27(2):106-109.
[11]	Wu M.Expressiong and significance of Moesin in human brain astrocytoma,and its influence on growth and invasion of U251 cell(Moesin在人脑星形细胞瘤中的表达和意义及其对U251细胞增殖和侵袭的影响)[D].Changsha:Zhongnan University,2010.
[12]	Zhu X,Morales FC,Agarwal NK,et al.Moesin is a glioma progression marker that induces proliferation and Wnt/beta-catenin pathway activation via interaction with CD44[J].Cancer Res,2013,73(3):1142-1155.
[13]	Liu C,Tao XF,Gao ZN,et al.Corrlation of Moesin and E-cadherin with invasion of papillary thyroid carcinoma[J].Canc Res Prev & Treat(肿瘤防治研究),2012,39(1):44-47.
[14]	Zhang LP,Pu HW,Chen X,et al.Expression of mRNA of matrix metalloproteinase 11 and Moesin and its relevance to metastasis and prognosis in colorectal carcinoma[J].J Cap Med Univ(首都医科大学学报),2012,33(5):575-580.
[15]	Desouza LV,Matta A,karim Z,et al.Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme[J].Mol Cancer,2013,12(74):1-13.
[16]	Kahsai AW,Zhu S,Wardrop DJ,et al.Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin,disrupting interactions of radixin with actin and CD44[J].Chem Biol,2006,13(9):973-983.
[17]	Giretti MS,Monttguevara MM,Cecchi E,et al.Effects of estetrol on migration and invasion in T47-D breast cancer cells through the actin cytoskeleton[J].Front Endocrinol,2014,5(80):1-8.
[18]	Wang CC,Liau JY,Lu YS,et al.Differential expression of moesin in breast cancers and its implication in epithelial-mesenchymal transition[J].Histopathology,2012,61(1):78-87.
[19]	Abiatari I, Esposito I, Oliveira TD, et al. Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer[J].J Cell Mol Med,2010,14(5):1166-1179.
[20]	Haynes J,Srivastava J,Madson N,et al.Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression[J].Mol Biol Cell,2011,22(24):4750-4764.
[21]	Chiang CD,Kanzawa F,Matsushima Y,et al.Antitumor activity of quinocarmycin against carcinoma of the lung in human tumor clonogenic assay[J].J Pharmacobiodyn,1987,10(9):431-435.
[22]	Fujimoto K,Oka T,Morimoto M.Antitumor activity of a novel antitumor antibiotic,quinocarmycin citrate(KW2152)[J].Cancer Res,1987,47(6):1516-1522.
[23]	Plowman J,Dykes DJ,Narayanan VL,et al.Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture kand in mice[J].Cancer Res,1995,55(4):862-867.
[24]	Saito H,Hirata T,Kasai M,et al.Synthesis and biological evaluation of quinocarcin derivatives:thioalkyl-substituted quinones and hydroquinones[J].J Med Chem,1991,34(7):1959-1966.
[25]	Saito H,Kobayashi S,Uosaki Y,et al.Synthesis and biological evaluation of quinocarcin derivatives[J].Chem Pharm Bull,1990,38(5):1278-1285.
[26]	Mirsalis JC,Schindler HJ,Hill JR,et al.Toxicity of a quinocarmycin analog,DX-52-1,in rats and dogs in relation to clinical outcome[J].Cancer Chemother Pharmacol,2003,51(3):193-201.

[1]	TANG Qian, CHEN Song, GAO Xiangdong. Advances of mechanisms of metabolic memory-based diabetic complications and therapeutic drugs[J]. Journal of China Pharmaceutical University, 2017, 48(5): 622-628. DOI: 10.11665/j.issn.1000-5048.20170519
[2]	WU Shiwei, ZHANG Hui, LI Qianbin, HU Gaoyun. Advances in thioredoxin reductase and its inhibitors[J]. Journal of China Pharmaceutical University, 2016, 47(5): 511-520. DOI: 10.11665/j.issn.1000-5048.20160502
[3]	XIN Minhang, ZHANG Sanqi. Advances in PI3Kδ selective inhibitors[J]. Journal of China Pharmaceutical University, 2016, 47(5): 503-510. DOI: 10.11665/j.issn.1000-5048.20160501
[4]	YAO Guilin, WANG Haiyong, LU Tao. Advances of the uricosuric drugs[J]. Journal of China Pharmaceutical University, 2016, 47(4): 491-496. DOI: 10.11665/j.issn.1000-5048.20160417
[5]	LIU Kejun, ZHANG Zhimin, RAN Ting, CHEN Hongli, LU Tao, CHEN Yadong. Advances in BET bromodomain protein inhibitors[J]. Journal of China Pharmaceutical University, 2015, 46(3): 264-271. DOI: 10.11665/j.issn.1000-5048.20150302
[6]	LI Tonghui, GUO Hao, LU Tao, WANG Yue, LU Shuai, TANG Weifang. Advances in the research of FLT3 inhibitors for acute myeloid leukemia[J]. Journal of China Pharmaceutical University, 2015, 46(2): 153-161. DOI: 10.11665/j.issn.1000-5048.20150203
[7]	WANG Xinning, XU Bin, ZHOU Jinpei, ZHANG Huibin. Advances of anti-diabetic drugs based on new targets[J]. Journal of China Pharmaceutical University, 2015, 46(2): 141-152. DOI: 10.11665/j.issn.1000-5048.20150202
[8]	LI Chunhong, DU Hongjin, WEN Xiao′an, SUN Hongbin. Advances in inhibitors of MDM2 and MDM4[J]. Journal of China Pharmaceutical University, 2015, 46(1): 1-15. DOI: 10.11665/j.issn.1000-5048.20150101
[9]	DENG Lian-bai, LI Ai-xiu, JIN Yu-rui. Advances in the study on inhibitors of RNase H,a novel anti-HIV drug target[J]. Journal of China Pharmaceutical University, 2011, 42(6): 578-584.
[10]	XU Si-sheng, ZHANG Hui-bin, ZHOU Jin-pei, HUANG Jian-jun. Advances of new antidiabetic drugs[J]. Journal of China Pharmaceutical University, 2011, 42(2): 97-106.

Cited By

Get Citation

XML

Article views (1384) PDF downloads (1099)

Turn off MathJax

Article Contents

Abstract

References

Roles of Moesin in tumor progression

Abstract

References

Related Articles

Catalog

Roles of Moesin in tumor progression

Abstract

References

Related Articles

Catalog

Export File

Citation

Format

Content