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HUANG Jingqun, WANG Jun, YIN Zhongxin, GUO Ruifeng, CHEN Jian, LIANG Huayin, LIU Yi. Comparative study of quercetin and allopurinol on serum uric acid levels and function of liver and kidney in hyperuricemic rats[J]. Journal of China Pharmaceutical University, 2015, 46(4): 458-463. DOI: 10.11665/j.issn.1000-5048.20150412
Citation: HUANG Jingqun, WANG Jun, YIN Zhongxin, GUO Ruifeng, CHEN Jian, LIANG Huayin, LIU Yi. Comparative study of quercetin and allopurinol on serum uric acid levels and function of liver and kidney in hyperuricemic rats[J]. Journal of China Pharmaceutical University, 2015, 46(4): 458-463. DOI: 10.11665/j.issn.1000-5048.20150412
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Comparative study of quercetin and allopurinol on serum uric acid levels and function of liver and kidney in hyperuricemic rats

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  • To investigate the therapeutic effect and influence of quercetin and allopurinol on the function of liver and kidney in hyperuricemic rats, male SD rats were administered with the drugs by oral gavage once a day for seven consecutive days throughout the experiment. On the fifth day, the animal model of hyperuricemia was set up by hypoxanthine intraperitoneal injection. The serum was used for assaying the uric acid(UA), alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), direct bilirubin(DBIL), β2-microglobulin(β2-MG), serum cystatin C(Cys-C), urea nitrogen(Urea)and serum creatinine(Cr)with colorimetry, continuous monitoring, chemical oxidation and enzyme-linked immunosorbent assay. The results showed that quercetin had no effect on the uric acid levels of serum, and that allopurinol reduced uric acid levels in rats significantly(P< 0. 01). The serum levels of AST and ALT in rats substantially decreased compared with normal control group(P< 0. 01), while no significant differences were found in TBIL, and DBIL. Compared with normal control group, β2-MG and Cys-C levels were significantly increased in the other five groups(P< 0. 01), serum levels of Urea and Cr were significantly higher in the allopurinol group compared to the normal control group(P< 0. 01). Modeling and administration group showed mild histopathological changes in rat kidney. The results clearly demonstrated that quercetin had no effect on the uric acid levels of serum, and allopurinol lowered uric acid significantly. There was no significant effect on the function of liver by modeling and administration, however, there was potential impaiment of renal function after modeling. Quercetin did not exhibit a protective effect on renal injury and administration with allopurinol increased kidney damage.
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  • [1]
    Curiel RV,Guzman NJ.Challenges associated with the management of gouty arthritis in patients with chronic kidney disease:a systematic review[J].Semin Arthritis Rheum,2012,42(2):166-178.
    [2]
    Shi L,Xu L,Yang Y,et al.Suppressive effect of modified simiaowan on experimental gouty arthritis:an in vivo and in vitro study[J].J Ethnopharmacol,2013,150(3):1038-1044.
    [3]
    Miles SL,McFarland M,Niles RM.Molecular and physiological actions of quercetin:need for clinical trials to assess its benefits in human disease[J].Nutr Rev,2014,72(11):720-734.
    [4]
    Huang J,Zhu M,Tao Y,et al.Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat[J].J Pharm Pharmacol,2012,64(8):1119-1127.
    [5]
    De Giorgio F,Abbate A,Zoccai GB,et al.An unusual cause of fatal pulmonary embolism[J].Int J Cardiol,2007,114(3):393-395.
    [6]
    Yao L,Dong W,Lu F,et al.An improved acute gouty arthritis rat model and therapeutic effect of rhizoma dioscoreae nipponicae on acute gouty arthritis based on the protein-chip methods[J].Am J Chin Med,2012,40(1):121-134.
    [7]
    Huang J,Wang S,Zhu M,et al.Effects of genistein,apigenin,quercetin,rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice[J].Food Chem Toxicol,2011,49(9):1943-1947.
    [8]
    Lapsia V,Johnson RJ,Dass B,et al.Elevated uric acid increases the risk for acute kidney injury[J].Am J Med,2012,125(3):302-317.
    [9]
    Jung JW,Kim JY,Yoon SS,et al.HLA-DR9 and DR14 are associated with the allopurinol-induced hypersensitivity in hematologic malignancy[J].Tohoku J Exp Med,2014,233(2):95-102.
    [10]
    Biagioni E,Busani S,Rinaldi L,et al.Acute renal failure and liver necrosis associated to allopurinol therapy[J].Anaesth Intensive Care,2012,40(1):190-191.
    [11]
    Liu W,Gao FF,Li Q,et al.Protective Effect of astragalus polysaccharides on liver injury induced by several different chemotherapeutics in mice[J].Asian Pac J Cancer Prev,2014,15(23):10413-10420.
    [12]
    Sun S,Chen G,Zheng S,et al.Analysis of clinical parameters that contribute to the misdiagnosis of biliary atresia[J].J Pediatr Surg,2013,48(7):1490-1494.
    [13]
    Liu D,Huang P,Li X,et al.Using inflammatory and oxidative biomarkers in urine to predict early acute kidney injury in patients undergoing liver transplantation[J].Biomarkers,2014,19(5):424-429.
    [14]
    Ruan ZB,Zhu L,Yin YG,et al.Cystatin C,N-terminal probrain natriuretic peptides and outcomes in acute heart failure with acute kidney injury in a 12-month follow-up:insights into the cardiorenal syndrome[J].J Res Med Sci,2014,19(5):404-409.
    [15]
    Gu H,Yang M,Zhao X,et al.Pretreatment with hydrogen-rich saline reduces the damage caused by glycerol-induced rhabdomyolysis and acute kidney injury in rats[J].J Surg Res,2014,188(1):243-249.
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