Advances of the graft copolymers of pullulan as pharmaceutical carriers

HUANG Liping; TU Jiasheng

doi:10.11665/j.issn.1000-5048.20150417

Journal of China Pharmaceutical University > 2015 > 46(4): 488-492. > DOI: 10.11665/j.issn.1000-5048.20150417

HUANG Liping, TU Jiasheng. Advances of the graft copolymers of pullulan as pharmaceutical carriers[J]. Journal of China Pharmaceutical University, 2015, 46(4): 488-492. DOI: 10.11665/j.issn.1000-5048.20150417

Citation:

PDF (1027 KB)

Advances of the graft copolymers of pullulan as pharmaceutical carriers

More Information

Graphical Abstract

Abstract

Abstract

Graft copolymerization is one of the most effective methods to improve the performance of pullulan and extend its applications. This paper attempts to review the recent progresses in the preparation and application of graft copolymers of pullulan as pharmaceutical carriers from different synthesized polymers and the properties of graft copolymers of pullulan. The problems of pullulan based graft copolymers in drug release system are expounded, and the future development in this field direction is presented.
- pullulan,
- copolymer,
- graft,
- drug release,
- advances

FullText(HTML)

References (32)

References

[1]	Kimoto T,Shibuya T,Shiobara S.Safety studies of a novel starch,pullulan:chronic toxicity in rats and bacterial mutagenicity[J].Food Chem Toxicol,1997,35(3/4):323-329.
[2]	Vipul DP,Jani GK,Khanda SM.Pullulan:an exopolysaccharide and its various applications[J].Carbohydr Polym,2013,95(1):540-549.
[3]	Kirill IS.Current knowledge on biosynthesis,biological activity,and chemical modification of the exopolysaccharide,pullulan[J].Carbohydr Res,2004,339(3):447-460.
[4]	Masako FK, Masato SO, Asako S, et al. Cholesteryl group-and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering[J].Biomaterials,2012,33(30):7613-7620.
[5]	Kazunari A, Seiichi K, Shozo S, et al. Self-assembled hydrogel nanoparticle of cholesterol-bearing pullulan as a carrier of protein drugs:complexation and stabilization of insulin[J].J Control Release,1998,54(3):313-320.
[6]	Junia MP,Michelle M,Kevin JE.Synthesis of amphiphilic 6-carboxypullulan ethers[J].Carbohydr Polym,2014,100:65-73.
[7]	Punna RR,Rahul V,Jagadeesh B,et al.Modified pullulan nanoparticles for oral delivery of lopinavir:Formulation and pharmacokinetic evaluation[J].Carbohydr Polym,2014,110:320-328.
[8]	Yang WZ,Wang MM,Ma LL,et al.Synthesis and characterization of biotin modified cholesteryl pullulan as a novel anticancer drug carrier[J].Carbohydr Polym,2014,99:720-727.
[9]	Gheorghe F,Marieta C,Paolo A.Preparation and characterization of pH-and temperature-sensitive pullulan microspheres for controlled release of drugs[J].Biomaterials,2008,29(18):2767-2775.
[10]	Mocanu G,Nichifor M,Picton L,et al.Preparation and characte-rization of anionic pullulan thermoassociative nanoparticles for drug delivery[J].Carbohydr Polym,2014,111:892-900.
[11]	Luminita G,Marieta C,Gheorghe F.Novel biodegradable flocculanting agents based on pullulan[J].J Hazard Mater,2010,181(1/2/3):351-358.
[12]	Rekha MR,Chandra P,Sharma H.Pullulan-polyethyleneimine conjugates for liver cell gene delivery:in vitro evaluation of cellular uptake,intracellular trafficking and transfection efficiency[J].Acta Biomater,2011,7(1):370-379.
[13]	Louiza BT,Jacek L,Kwang SK,et al.Gene delivery by pullulan derivatives in brain capillary endothelial cells for protein secretion[J].J Control Release,2011,151(1):45-50.
[14]	Hu Y, Wang JS,Zhang H,et al.Synthesis and characterization of monodispersed P(St-co-DMAEMA)nanoparticles as pH-sensitive drug delivery system[J].Mater Sci Eng C,2014,45:1-7.
[15]	Yan HX,Jin B,Gao SH,et al.Equilibrium swelling and electrochemistry of polyampholytic pH-sensitive hydrogel[J].Int J Solids Struct,2014,51(23/24):4149-4156.
[16]	Guo H,Liu YY,Wang Y,et al.pH-sensitive pullulan-based nanoparticle carrier for adriamycin to overcome drug-resistance of cancer cells[J].Carbohydr Polym,2014,111:908-917.
[17]	Dulong V,Mocanu G,Cerf DL.A novel amphiphilic pH-sensitive hydrogel based on pullulan[J].Colloid Polym Sci,2007,285(10):1085-1091.
[18]	Marieta C,Ionut M,Ionela O,et al.Studies on graft copolymerization of 3-acrylamidopropyl trimethylammonium chloride on pullulan[J].Carbohydr Polym,2011,84(3):926-932.
[19]	Anca GG,Marieta C,Vasile CG,et al.Studies on physico-chemical and antibacterial properties of graftedpullulans solutions[J].React Funct Polym,2013,73(9):1249-1254.
[20]	Cohn D,Lando G,Sosnik A.PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers[J].Biomaterials,2006,27(9):1718-1727.
[21]	Paquet O,Krouit M,Bras J,et al.Surface modification of cellulose by PCL grafts[J].Acta Mater,2010,58(3):792-801.
[22]	Guo YZ,Wang XH,Shen ZG,et al.Preparation of cellulose-graft-poly(ε-caprolactone)nanomicelles by homogeneous ROP in ionic liquid[J].Carbohydr Polym,2013,92(1):77-83.
[23]	Lizebona AA,Rekh MR.Betaine conjugated cationic pullulan as effective gene carrier[J].Int J Biol Macromol,2015,72:819-826.
[24]	Young IJ,Hee SN,Jong SO,et al.Adriamycin release from self-assembling nanospheres of poly(dl-lactide-co-glycolide)-grafted pullulan[J].Int J Pharm,2006,322(1/2):154-160.
[25]	Seo S,Lee CS,Jung YS,et al.Thermo-sensitivity and triggered drug release of polysaccharide nanogels derived from pullulan-g-poly(l-lactide)copolymers[J].Carbohydr Polym,2012,87(2):1105-1111.
[26]	Tang XJ,Huang J,Xu LY,et al.Microwave-assisted rapid synthesis,characterization and application of poly(d,l-lactide)-graft-pullulan[J].Carbohydr Polym,2014,107:7-15.
[27]	LI JB,Ren J.Progress of the graft copolymers of poly(lactic acid)[J].Mater Rev(材料报道),2010,24(12):86-90.
[28]	Park JS,Park JK,Nam JP,et al.Preparation of pullulan-g-poly(L-lysine)and its evaluation as a gene carrier[J].Macromol Res,2012,20(7):667-672.
[29]	Scomparin A,Salmaso S,Bersani S,et al.Novel folated and non-folated pullulan bioconjugates for anticancer drug delivery[J].Eur J Pharm Sci,2011,42(5):547-558.
[30]	Yanga XC,Niub YL,Zhao NN,et al.A biocleavable pullulan-based vector via ATRP for liver cell-targeting gene delivery[J].Biomaterials,2014,35(12):3873-3884.
[31]	Wang JY, Dou BR, Bao YM. Efficient targeted pDNA/siRNA delivery with folate-low-molecular-weight polyethyleneimine-modified pullulan as non-viral carrier[J].Mater Sci Eng C,2014,34:98-109.
[32]	Wang JY,Cui S,Bao YM,et al.Tocopheryl pullulan-based self assembling nanomicelles for anti-cancer drug delivery[J].Mater Sci Eng C,2014,43:614-621.

Cited By

Get Citation

PDF

XML

Article views (1137) PDF downloads (2098)

Turn off MathJax

Article Contents

Abstract

References

Advances of the graft copolymers of pullulan as pharmaceutical carriers

Abstract

References

Catalog

Export File

Citation

Format

Content