Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis

SHEN Kai; KOU Junping; YU Boyang

doi:10.11665/j.issn.1000-5048.20150503

Journal of China Pharmaceutical University > 2015 > 46(5): 532-540. > DOI: 10.11665/j.issn.1000-5048.20150503

SHEN Kai, KOU Junping, YU Boyang. Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis[J]. Journal of China Pharmaceutical University, 2015, 46(5): 532-540. DOI: 10.11665/j.issn.1000-5048.20150503

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Research advances in the mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis

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Abstract

Oxidative stress-induced neuronal apoptosis plays a vital role in the development of neurodegenerative disorders, while at present its regulation pathways mainly include the NF-κB pathway, p53 pathway, MAPK pathway, PI3K/Akt pathway, Nrf2 pathway, as well as other signaling pathways. Research findings suggest that the active components in Chinese materia medica exert significant biological activities in the treatment of oxidative stress-induced neuronal apoptosis. In the present paper, we review the recent research advances on the relative mechanisms of active components in Chinese materia medica against oxidative stress-induced neuronal apoptosis, so as to provide some references or clues for the clarification of possible mechanisms of active components in Chinese materia medica and the treatment of related neurodegenerative diseases.
- active components in Chinese materia medica,
- neuron,
- oxidative stress,
- apoptosis,
- neurodegenerative disease

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