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YUAN Duo, ZHU Xiong, ZHANG Shijin, WANG Duo, LI Zhiyu, SUN Liping. Analysis and synthesis of the related substances of palbociclib[J]. Journal of China Pharmaceutical University, 2015, 46(6): 696-699. DOI: 10.11665/j.issn.1000-5048.20150610
Citation: YUAN Duo, ZHU Xiong, ZHANG Shijin, WANG Duo, LI Zhiyu, SUN Liping. Analysis and synthesis of the related substances of palbociclib[J]. Journal of China Pharmaceutical University, 2015, 46(6): 696-699. DOI: 10.11665/j.issn.1000-5048.20150610
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Analysis and synthesis of the related substances of palbociclib

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    • Abstract
  • To strengthen the quality control of palbociclib, three related substances were separated from the bulk drug. These substances were identified as 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido ［2, 3-d］ pyrimidin-7(8H)-one( A ), 8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridine-2-yl)amino)-6-vinylpyrido ［2, 3-d］ pyrimidin-7(8H)-one( B ), tert-butyl4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido ［2, 3-d］ pyrimidin-2-yl)amino)pyridin-3-yl)piperazi-ne-1-carboxylate( C ). Based on the structures of the impurities, the possible routes to them were discussed, and their structures were elucidated by 1H NMR and MS.
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    • References (5)
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