Citation: | LIU Yan, WANG Tingting, CHEN Li. Synthesis and antitumor activity of isosteviol derivatives[J]. Journal of China Pharmaceutical University, 2016, 47(1): 48-53. DOI: 10.11665/j.issn.1000-5048.20160106 |
[1] |
Nordentoft I, Jeppesen PB, Hong J, et al. Isosteviol increases insulin sensitivity and changes gene expression of key insulin regulatory genes and transcription factors in islets of the diabetic KKAy mouse[J].Diabetes Obes Metab,2008,10(10):939-949.
|
[2] |
Ma J,Ma Z,Wang J,et al.Isosteviol reduces plasma glucose levels in the intravenous glucose tolerance test in Zucker diabetic fatty rats[J].Diabetes Obes Metab,2007,9(4):597-599.
|
[3] |
Xu D,Li Y,Wang J,et al.The cardioprotective effect of isosteviol on rats with heart ischemia-reperfusion injury[J].Life Sci,2007,80(4):269-274.
|
[4] |
Lin LH,Lee LW,Sheu SY,et al.Study on thestevioside analogues of steviolbioside steviol and isosteviol 19-alkyl amide dimers:synthesis and cytotoxic and antibacterial activity[J].Chem Pharm Bull,2004,52(9):1117-1122.
|
[5] |
Wong KL, Lin JW, Liu JC, et al. Antiproliferative effect of isosteviol on angiotensin-II- treated rat aortic smooth muscle cells[J].Pharmacology,2006,76(4):163-169.
|
[6] |
Wu Y,Liu CJ,Liu X,et al.Stereoselective synthesis,characterization,and antibacterial activities of novel isosteviol derivatives with D-Ring modification[J].Helv Chim Acta,2010,93(10):2052-2069.
|
[7] |
Lohoelter C,Weckbecker M,Waldvogel SR.(-)-Isosteviol as a versatile ex-chiral-pool building block for organic chemistry[J].Eur J Org Chem,2013,2013(25):5539-5554.
|
[8] |
Mosettig E,Beglinger U,Quitt P,et al,The absolute configuration of steviol and isosteviol[J].J Am Chem Soc,1963,85(15):2305-2309.
|
[9] |
Dolder F,Lichti H,Mosettig E,et al.The structure and stereochemistry of steviol and isosteviol[J].J Am Chem Soc,1960,82(1):246-247.
|
[10] |
Wu Y,Dai GF,Yang JH,et al.Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic acti-vities[J].Bioorg Med Chem Lett,2009,19(6):1818-1821.
|
[11] |
Wang TT,Liu Y,Chen L.Synthesis and cytotoxic activity of nitric oxide-releasing isosteviol derivatives[J].Bioorg Med Chem Lett,2014,24(9):2202-2205.
|
[12] |
Wang J,Liu H.Application of nitrile in drug design[J].Chin J Org Chem(有机化学),2012,32(9):1643-1652.
|
[13] |
Qiao YX,Mao Y,Huang ZJ,et al.Synthesis and antitumor activities of novel CDDO-Me analogues[J].J China Pharm Univ(中国药科大学学报),2015,46(1):16-27.
|
[14] |
Zhao GS.Design,synthesis and anticancer activity of α,β-unsaturated carbonly derivatives(GSTπ抑制剂α,β-不饱和酮衍生物的设计、合成及其抗肿瘤活性研究)[D].Jinan:Shandong University,2006.
|
[15] |
Hutt OE,Doan TL,Georg GI.Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol[J].Org Lett,2013,15(7):1602-1605.
|
[16] |
Liu JH,Tang J,Zhu ZF,et al.Design,synthesis,and anti-tumor activity of novel betulinic acid derivatives[J].J Asian Nat Prod Res,2014,16(1):34-42.
|
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