Synthesis of the related substances of deferasirox

LUO Yan; GU Jinhua; LUO Zhiteng; WU Jie; YE Lianbao

doi:10.11665/j.issn.1000-5048.20160306

Journal of China Pharmaceutical University > 2016 > 47(3): 288-290. > DOI: 10.11665/j.issn.1000-5048.20160306

LUO Yan, GU Jinhua, LUO Zhiteng, WU Jie, YE Lianbao. Synthesis of the related substances of deferasirox[J]. Journal of China Pharmaceutical University, 2016, 47(3): 288-290. DOI: 10.11665/j.issn.1000-5048.20160306

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Synthesis of the related substances of deferasirox

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To perform the quality control of deferasirox and establish its quality criterion, three related substances which were determined by analyzing the synthetic route were synthesized, and their structures were confirmed by ¹H NMR and MS. These substances were 2-(2-hydroxyphenyl)-4H-benzo［1, 3-e］oxazin-4-one(A), 2-hydroxy-N-(2-hydroxyben-zoyl)-benzamide(B), and methyl-4-［3, 5-bis(2-hydroxyphenyl)- 1H- ［1, 2, 4］triazol-1-yl］-benzoate(C).
- deferasirox,
- related substances,
- synthesis

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