Isolation and identification of anti-inflammatory constituents from<i> Houttuynia cordata</i>

XU Guijun; LI Zhijun; WANG Qi; TAN Jiejun; SHI Guoshan; QI Wei; LI Di; WANG Youpeng

doi:10.11665/j.issn.1000-5048.20160308

Journal of China Pharmaceutical University > 2016 > 47(3): 294-298. > DOI: 10.11665/j.issn.1000-5048.20160308

XU Guijun, LI Zhijun, WANG Qi, TAN Jiejun, SHI Guoshan, QI Wei, LI Di, WANG Youpeng. Isolation and identification of anti-inflammatory constituents from Houttuynia cordata[J]. Journal of China Pharmaceutical University, 2016, 47(3): 294-298. DOI: 10.11665/j.issn.1000-5048.20160308

Citation:

PDF (1068 KB)

Isolation and identification of anti-inflammatory constituents from Houttuynia cordata

More Information

Graphical Abstract

Abstract

Abstract

Ten compounds were isolated and purified from the ethyl acetate fraction of Houttuynia cordata by silica gel and ODS column chromatographies. The chemical structures of the compounds were identified on the basis of physicochemical properties as well as spectral data. These isolated compounds were elucidated as sequinoside L( 1 ), a new phenolic glycoside, together with nine known compounds, including sequinoside K( 2 ), methyl chlorogenate( 3 ), chlorogenic acid( 4 ), hydroquinone( 5 ), vanillic acid( 6 ), hyperin( 7 ), isoquercitrin( 8 ), quercetin( 9 ), and quercitrin( 10 ). In addition, the anti-inflammatory activities of compounds 1 - 10 were evaluated in LPS-induced RAW264. 7 macrophages. Among them, compounds 1 , 2 , 6 and 9 showed potent anti-inflammatory activity which was similar to that of positive control dexamethasone.
- Houttuynia cordata,
- phenolic glycoside,
- anti-inflammatory activity,
- chemical constituents,
- structural identification

FullText(HTML)

References (14)

References

[1]	Dicpinigaitis PV.Chronic cough due to asthma:ACCP evidence-based clinical practice guidelines[J].Chest,2006,129(1 Suppl):75S-79S.
[2]	Liu GL,Lin JT.Unexplained cause of chronic cough and clinical features of composition analysis[J].Chin J Tuberc Respir Dis(中华结核和呼吸杂志),2009,32(6):422-425.
[3]	Wang LM,Xia XZ.Inhaled corticosteroid treatment of cough variant asthma treatment observation of the Chinese community physicians[J].Chin Community Doctors(中国社区医师),2010,12(13):90.
[4]	Miao Q,Wei PC,Fan MR,et al.Clinical study on treatment of cough variant asthma by Chinese medicine[J].Chin J Integr Med(中国结合医学杂志),2013,19(7):539-545.
[5]	Zhang ZD,Deng YQ,Zhang Y,et al.TCM differential treatment of cough variant asthma[J].J Tradit Chin Med(中医杂志),2010,30(1):60-63.
[6]	Kanchanapoom T,Kasai R,Yamasaki K.Phenolic glycosides from Markhamia stipulate[J].Phytochemistry,2002,59:557-563.
[7]	Mu LH,Li HJ,Guo DH,et al.Cycloartane-type triterpene glycosides from Beesia calthaefolia and their anticompoement activity[J].J Nat Med,2014,68:604-609.
[8]	Gao YP,Shen YH,Zhang SD,et al.Incarvilleatone,a new cyclohexylethanoid dimer from Incarvillea younghusbanii and its inhibition against nitric oxide(NO)release[J].Org Lett,2012,14(8):1954-1957.
[9]	Zhong XN,Otsuka H,Ide T,et al.Hydroquinone diglycoside acyl esters from the leaves of Myrsine seguinii[J].Phytochemistry,1999,52:923-927.
[10]	Shen SM,Zhang J,Li GZ,et al.Chemical constituents of the aerial parts of Emilia sonchifolia(II)[J].Chin Pharm J(中国药学杂志),2013,48(21):1815-1819.
[11]	Deng XH,Zheng CJ,Wu Y,et al.Chemical constituents of whole plant of Veronicastrum axillare(Sieb.Et Zucc.)Yamazaki[J].Chin Pharm J(中国药学杂志),2013,48(10):777-781.
[12]	Luo L,Li ZQ,Ma GY.Flavonoids and spiro-lactones from Hypericum hookerianum[J].Chin Tradit Herb Drugs(中草药),2005,36(1):17-20.
[13]	Yi X,Shi JG,Zhong GX,et al.Studies on the chemical constituents in the leaves of Cyclocarya paliurus[J].Chin J Chin Mater Med(中国中药杂志),2002,27(1):43-45.
[14]	Gong JQ,Jiang CX,Chen X,et al.Studies on flavonoids from the eaves of Engelhardia roxburghiana[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(7):813-817.

Cited By

Get Citation

PDF

XML

Article views (1809) PDF downloads (2638)

Turn off MathJax

Article Contents

Abstract

References

Isolation and identification of anti-inflammatory constituents from Houttuynia cordata

Abstract

References

Catalog

Export File

Citation

Format

Content