Advances in the mechanism research of natural products against acute lung injury

YU Sulan; YU Xiu; KOU Junping

doi:10.11665/j.issn.1000-5048.20160403

Journal of China Pharmaceutical University > 2016 > 47(4): 397-403. > DOI: 10.11665/j.issn.1000-5048.20160403

YU Sulan, YU Xiu, KOU Junping. Advances in the mechanism research of natural products against acute lung injury[J]. Journal of China Pharmaceutical University, 2016, 47(4): 397-403. DOI: 10.11665/j.issn.1000-5048.20160403

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Advances in the mechanism research of natural products against acute lung injury

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Abstract

Abstract

Acute lung injury(ALI)is a common critical disease with increasing morbidity and mortality rate in clinic. Its major pathological cause is the inflammation imbalance, which can cause diffuse alveolar and pulmonary vascular endothelial cell injury, lung edema and atelectasis. Many pathways and receptors, such as NF-κB and MAPK signaling pathways, and the adenosine A_2A receptors, Toll-like receptors(TLRs), peroxisome proliferator-activated receptor gamma(PPARγ), etc. are involved in ALI. Nowadays, prevention and treatment of ALI with natural products attract more and more attention. This article reviews the advances in the mechanisms research of natural products in recent three years against ALI so as to provide some references and clues for the development of innovative drugs to prevent and treat ALI.
- natural products,
- acute lung injury,
- pathological characteristics,
- signal pathways,
- receptors

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