• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
ZHAO Juanzhi, WANG Cong, LI Jindian, ZHANG Dongjian, ZHANG Jian, YIN Zhiqi. Metabolites of hypericin in rats in vivo[J]. Journal of China Pharmaceutical University, 2016, 47(4): 457-462. DOI: 10.11665/j.issn.1000-5048.20160411
Citation: ZHAO Juanzhi, WANG Cong, LI Jindian, ZHANG Dongjian, ZHANG Jian, YIN Zhiqi. Metabolites of hypericin in rats in vivo[J]. Journal of China Pharmaceutical University, 2016, 47(4): 457-462. DOI: 10.11665/j.issn.1000-5048.20160411

Metabolites of hypericin in rats in vivo

More Information
  • The study aimed to separate and identify the metabolites of hypericin in the bile and necrotic tissues in rats. After intravenous injection of 10 mg/kg hypericin, 0-12 h bile of normal rats and 24 h necrotic liver of rats with reperfused hepatic infarction were collected, and metabolites of rats were analyzed by high performance liquid chromatography coupled with electrospray tandemtime of flight mass spectrometry(HPLC-TOF/MS). The prototype(M0)and three glycosylation metabolites(M1, M2, M3)of hypericin in rat bile and the parent compound in rat necrotic liver were detected and identified. Results indicated that prototype and glycosylation of hypericin were the major metabolic form in rat bile and the parent compound was found only in necrotic tissues.
  • [1]
    Cooper EH, Bedford AJ, Kenny TE. Cell death in normal and malignant tissues[J].Adv Cancer Res,1975,21:59-120.
    [2]
    Smith BA,Smith BD.Biomarkers and molecular probes for cell death imaging and targeted therapeutics[J].Bioconjug Chem,2012,23(10):1989-2006.
    [3]
    Chen SL, Yu LK, Jiang CY, et al. Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer[J].J Clin Oncol,2005,23(7):1538-1547.
    [4]
    Li J, Oyen R, Verbruggen A, et al. Small molecule sequential dual-targeting theragnosticstrategy(SMSDTTS):from preclinical experiments towards possible clinical anticancer applications[J].J Cancer,2013,4(2):133-145.
    [5]
    Van de Putte M,Marysael T,Fonge H,et al.Radiolabelediodohypericin as tumor necrosis avid tracer:diagnostic and therapeutic potential[J].Int J Cancer,2012,131(2):E129-E137.
    [6]
    Kerb R,Brockmller J,Staffeldt B,et al.Single-dose and steady-state pharmacokinetics of hypericin and pseudohypericin[J].Antimicrob Agents Chemother,1996,40(9):2087-2093.
    [7]
    Kamuhabwa AAR,Di Mavungu JD,Baert L,et al.Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder[J].Eur J Pharm Biopharm,2005,59(3):469-474.
    [8]
    Kong M,Zhang J,Jiang CH,et al.Necrosis affinity evaluation of 131I-hypericin in a rat model of induced necrosis[J].J Drug Target,2013,21(6):604-610.
    [9]
    Yan YT,LaiChang JS,Li P,et al.Metabolites of salvianolic acid C in rats[J].J China Pharm Univ (中国药科大学学报),2013,44(5):442-446.
    [10]
    Zhang YQ, Long T, Niu YJ, et al. Research progress in oral absorption and metabolism of natural anthraquinones[J].Strait Pharm J (海峡药学),2014,26(7):1-5.
    [11]
    Song R,Xu L,Xu FG,et al.Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatography-tandem mass spectrometry[J].Biomed Chromatogr,2011,25(3):417-426.
    [12]
    Song R,Lin H,Zhang ZJ,et al.Profiling the metabolic differences of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition[J].Rapid Commun Mass Spectrom,2009,23(4):537-547.
    [13]
    Song R,Xu FG,Zhang ZJ,et al.Structural elucidation of in vitro metabolites of emodin by liquid chromatography-tandem mass spectrometry[J].Biomed Chromatogr,2008,22(11):1230-1236.
    [14]
    Liu W,Zheng ZJ,Liu X,et al.Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide[J].J Pharm Biomed Anal,2011,54(5):1157-1162.
    [15]
    Wan JB,Bai X,Cai XJ,et al.Chemical differentiation of Da-Cheng-Qi-Tang,a Chinese medicine formula,prepared by traditional and modern decoction methods using UPLC/Q-TOFMS-based metabolomics approach[J].J Pharmaceut Biomed Analy,2013,83:34-42.
    [16]
    Bánó G,Staniová J,Jancura D,et al.On the diffusion of hypericin in dimethylsulfoxide/water mixtures—the effect of aggregation[J].J Phys Chem B,2011,115(10):2417-2423.
    [17]
    Liu XJ,Jiang CH,Li Y,et al.Evaluation of hypericin:effect of aggregation on targeting biodistribution[J].J Pharm Sci,2015,104(1):215-222.
    [18]
    Yang J,Qian DW,Duan JA,et al.Advances in studies on metabolism of constituents in Chinese materiamedica by intestinal bacteria[J].Chin Tradit Herb Drugs (中草药),2011,42(11):2335-2344.
  • Related Articles

    [1]TU Penghuang, YAO Zhiren, JIN Meiling, NING Guanyu, HUANG Yaping, PAN Ke, YIN Zhiqi. Study of glycosides from Piper sintenense Hatusima[J]. Journal of China Pharmaceutical University, 2024, 55(2): 202-208. DOI: 10.11665/j.issn.1000-5048.2023122704
    [2]CAI Caihong, ZHENG Hao, GAI Cuijuan, DAI Haofu, MEI Wenli, CHEN Huiqin. Secondary metabolites of the endophytic fungus Aspergillus sp.Dq-25 from barnacle[J]. Journal of China Pharmaceutical University, 2023, 54(1): 62-67. DOI: 10.11665/j.issn.1000-5048.20220531001
    [3]FANG Siyang, ZHANG Xinggui, YE Yu, WANG Keqing, YAO Zhiren, HUANG Yaping, ZHANG Jian, QIN Yanhua, YIN Zhiqi. A new ester glycoside compound from Cyclocarya paliurus[J]. Journal of China Pharmaceutical University, 2023, 54(1): 56-61. DOI: 10.11665/j.issn.1000-5048.20221209002
    [4]XIE Jing, FAN Chunlin, XU Jie, ZHANG Jian, YE Wencai, ZHANG Xiaoqi. Alkaloids of Ervatamia pandacaqui[J]. Journal of China Pharmaceutical University, 2021, 52(3): 287-292. DOI: 10.11665/j.issn.1000-5048.20210304
    [5]ZHANG Yilun, ZHAO Xinyi, DONG Shubo, DONG Chao, SHEN Wenbin, DONG Haijuan. Isolation and identification of unknown impurities of alogliptin benzoate[J]. Journal of China Pharmaceutical University, 2020, 51(4): 488-493. DOI: 10.11665/j.issn.1000-5048.20200415
    [6]TAO Junjie, YANG Jie, WEN Xiaodong. Studies on the chemical constituents in the aerial parts of Paris polyphylla var. Yunnanensis[J]. Journal of China Pharmaceutical University, 2020, 51(4): 454-460. DOI: 10.11665/j.issn.1000-5048.20200410
    [7]HUANG Qilong, ZHANG Wanjin, LI Yan, CHEN Juan, ZHOU Baoping, ZOU Xiaohan, ZHANG Chunlei, CAO Zhengyu. Alkaloid constituents from Corydalis decumbens[J]. Journal of China Pharmaceutical University, 2017, 48(5): 563-567. DOI: 10.11665/j.issn.1000-5048.20170509
    [8]WANG Jingyi, DONG Yangyang, QI Chulu, ZHANG Jiayao, ZHANG Minjie, WANG Hao. Chemical constituents of the stem bark of Bombax ceiba L.[J]. Journal of China Pharmaceutical University, 2016, 47(5): 570-574. DOI: 10.11665/j.issn.1000-5048.20160511
    [9]YANG Hanbing, YANG Wenqiang, SONG Min, ZHANG Jian, ZHANG Xiaoqi, YE Wencai. Phenolic constituents of Galla Chinensis and their antiviral activities[J]. Journal of China Pharmaceutical University, 2016, 47(5): 566-569. DOI: 10.11665/j.issn.1000-5048.20160510
    [10]Isolation and Identification of Two Taxane DiterpenoidCompounds[J]. Journal of China Pharmaceutical University, 2001, (3): 32-34.

Catalog

    Article views (974) PDF downloads (1519) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return