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SUN Yinxing, WU Ying, SONG Heng, CHENG Jian, AO Guizhen. Synthesis and biological evaluation of H2S donor memantine derivatives[J]. Journal of China Pharmaceutical University, 2016, 47(5): 543-547. DOI: 10.11665/j.issn.1000-5048.20160506
Citation: SUN Yinxing, WU Ying, SONG Heng, CHENG Jian, AO Guizhen. Synthesis and biological evaluation of H2S donor memantine derivatives[J]. Journal of China Pharmaceutical University, 2016, 47(5): 543-547. DOI: 10.11665/j.issn.1000-5048.20160506
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Synthesis and biological evaluation of H2S donor memantine derivatives

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  • H2S has a role of protecting neurons from ischemia-reperfusion injury and significantly reducing the cerebral infarction area, but high concentration of H2S can induce neurotoxicity. Memantine, a N-methyl-D-aspartic acid(NMDA)receptor antagonist, could reduce the neurotoxicity of H2S at high concentration. Nine novel structures(compounds I 1- I 9)were designed by coupling(4-hydroxy phenyl)-3H-1, 2-dithiole-3-thione(ADT-OH)with memantine through alkanes as linkers and synthesized by four-step reactions from ADT-OH. Their neuroprotection against damage induced by glutamate on HT-22 cells was evaluated by MTT method. The results indicated that these compounds markedly increased the survival rates of damaged HT-22 cells at the concentration of 1 μmol/L(P< 0. 01), which suggested that these compounds could preferably protect neurons against damage induced by glutamate.
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  • [1]
    Yu F,Zhao J,Tang CS,et al.Effect of synthesized GYY4137,a slowly releasing hydrogen sulfide donor,on cell viability and distribution of hydrogen sulfide in mice[J].J Peking Univ(Health Sci),2010,42(5):493-497.
    [2]
    Cheung NS,Peng ZF,Chen MJ,et al. Hydrogen sulfide induced neuronal death occurs via glutamate receptor and is associated with calpain activation and lysosomal rupture in mouse primary cortical neurons[J].Neuropharmacology,2007,53(4):505-514.
    [3]
    Wildburger NC, Lin-Ye A, Baird MA, et al. Neuroprotective effects of blockers for T-type calcium channels[J].Mol Neurodegener,2009,4:44.
    [4]
    Kurokawa Y,Sekiguchi F,Kubo S,et al.Involvement of ERK in NMDA receptor-independent cortical neurotoxicity of hydrogen sulfide[J].Biochem Biophys Res Commun,2011,414(4):727-732.
    [5]
    Kumar S. Memantine: pharmacological properties and clinical uses[J].Neurol India,2004,52(3):307-309.
    [6]
    Szczesny B,Módis K,Yanagi K,et al.AP39,a novel mitochondria-targeted hydrogen sulfide donor,stimulates cellular bioenergetics,exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro[J].Nitric Oxide,2014,41:120-130.
    [7]
    Tomasova L,Pavlovicova M,Malekova L,et al.Effects of AP39,a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor,on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels[J].Nitric Oxide,2015,46:131-144.
    [8]
    Jia J,Xiao Y,Wang W,et al.Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress[J].Neurochem Int,2013,62(8):1072-1078.
    [9]
    Zhou X,Cao Y,Ao G,et al.CaMKK beta-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation[J].Antioxid Redox Signal,2014,21(12):1741-1758.
    [10]
    Huang B,Ao GZ,Yu J,et al.Synthesis of memantine derivatives[J].Chin J Synth Chem(合成化学),2009,17(1):120-122.
    [11]
    Wang X,Wang L,Sheng X,et al.Design,synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents[J].Org Biomol Chem,2014,12(31):5995-6004.
    [12]
    Maher P,Salgado KF,Zivin JA,et al.A novel approach to screening for new neuroprotective compounds for the treatment of stroke[J].Brain Res,2007,1173:117-125.
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