• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
YANG Hanbing, YANG Wenqiang, SONG Min, ZHANG Jian, ZHANG Xiaoqi, YE Wencai. Phenolic constituents of Galla Chinensis and their antiviral activities[J]. Journal of China Pharmaceutical University, 2016, 47(5): 566-569. DOI: 10.11665/j.issn.1000-5048.20160510
Citation: YANG Hanbing, YANG Wenqiang, SONG Min, ZHANG Jian, ZHANG Xiaoqi, YE Wencai. Phenolic constituents of Galla Chinensis and their antiviral activities[J]. Journal of China Pharmaceutical University, 2016, 47(5): 566-569. DOI: 10.11665/j.issn.1000-5048.20160510
shu

Phenolic constituents of Galla Chinensis and their antiviral activities

More Information
    Graphical Abstract
    • Abstract
  • Seven compounds in the 95% ethanol extract of Galla Chinensis were isolated by silica gel, ODS, Toyopearl HW-40(s)and RP-HPLC. Their structures were identified on the basis of spectral data and physicochemical properties as benzoic acid, 3, 4-dihydroxy-5-［(3, 4, 5-trihydroxybenzoyl)oxy］-, 5-ethoxycarbonyl-2, 3-dihydroxyphenyl ester( 1 ), trigallic acid( 2 ), 1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose( 3 ), shikimic acid( 4 ), gallic acid( 5 ), methyl gallate( 6 )and ethyl gallate( 7 ). Among them, compound 1 was a novel compound, and compound 2 was firstly isolated from the Galla Chinensis. The inhibition tests of the constituents showed that compound 3 exhibited in vitro antiviral activity against HSV-1 and RSV A strain, RSV Long strain with IC50 values of 13. 3, 3. 3, 3. 3 mmol/L, respectively.
    • FullText(HTML)
    • References (11)
  • [1]
    Editorial Board of the Flora of China.Flora of China(中国植物志)[M].Beijing:Science Press,1980,45(1):105.
    [2]
    Li CY,Ding WJ,Qu GR,et al.Chemical constituents of Galla Chinensis[J].China Tradit Herb Drugs(中草药),2008,39(8):1129-1130.
    [3]
    Zheng GM,Xu LX,Wu P,et al.Chemical constituents from pericarp of longan fruits[J].China Tradit Herb Drugs(中草药),2011,42(8):1485-1489.
    [4]
    Cho JY,Sohn MJ,Lee J,et al.Isolation and identification of pentagalloylglucose with broad-spectrum antibacterial activity from Rhus trichocarpa Miquel[J].Food Chem,2010,123(2):501-506.
    [5]
    Chang B, Xiao LJ, Zhang J, et al. Chemical constituents from Abies ernestii var.Salouenensis[J].J China Pharm Univ(中国药科大学学报),2014,45(1):43-47.
    [6]
    Tan JJ,Yang L,Du ZQ,et al.Chemical constituents in roots of Paeonia lactiflora[J].China Tradit Herb Drugs(中草药),2010,41(8):1245-1248.
    [7]
    Ding G,Liu YZ,Song MP,et al.Ployphenols from Terminalia chebula[J].J China Pharm Univ(中国药科大学学报),2001,32(3):193-196.
    [8]
    Wang RR,Gu Q,Wang HY,et al.Anti-HIV-1 activities of compounds isolated from the medicinal plant Rhus chinensis[J].J Ethnopharmacol,2008,117(1):249-256.
    [9]
    Li HX.Study on inhibition efficiency and relative mechanism of several antiviral agents to control tobacco mosaic virus(几种抗病毒药剂对烟草花叶病毒的抑制作用及相关机理研究)[D].Agricultural University of Hebei,2010.
    [10]
    Xie ZC,Chen ZP,Wu ZB,et al.Experimental study on screening of Chinese herbal medicine for anti-hepatitis B surface antigen(HBsAg)[J].Chin J Integr Med(中国中西医结合杂志),2002,22(6):139-141.
    [11]
    Duan D,Li ZQ,Luo HP,et al.Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease[J].Bioorg Med Chem Lett,2004,14(24):6041-6044.
    • Related Articles

  • Related Articles

    [1]ZENG Jingxia, ZHOU Wei, JIANG Yuteng, XUE Chunling. Antiviral and anti-inflammatory mechanism of Anti-601 Mixture based on network pharmacology and molecular docking[J]. Journal of China Pharmaceutical University, 2020, 51(5): 577-583. DOI: 10.11665/j.issn.1000-5048.20200509
    [2]WANG Jun, CAI Lingqiao, YAN Dong, GUO Min, WANG Qing, ZHANG Jian, YIN Zhiqi. Antiviral activities of flavonoids and diterpenoids isolated from Isodon eriocalyx(Dunn.)Hara[J]. Journal of China Pharmaceutical University, 2018, 49(5): 580-586. DOI: 10.11665/j.issn.1000-5048.20180510
    [3]OU Yu, FU Xiaozhong, ZHA Yufeng, ZHANG Shun, SU Hang, DONG Yongxi. Synthesis and biological evaluation of mixed phosphonate derivatives of substituted acyclonucleoside phosphonates[J]. Journal of China Pharmaceutical University, 2014, 45(6): 649-656. DOI: 10.11665/j.issn.1000-5048.20140605
    [4]CAO Jin-ming, WU Yan-jun, ZHU Chong-quan, HUANG Wen-long. Synthesis and anti-virus activities of 1,2,4-oxadiazole-phenoxy alkyl-isoxazole derivatives[J]. Journal of China Pharmaceutical University, 2011, 42(4): 299-304.
    [7]Synthesis of Antiviral Agent Pleconaril[J]. Journal of China Pharmaceutical University, 2004, (5): 92-94.
    [8]Synthesis and Antiviral Activity of Astragalus mongholicus Polysaccharide Sulfate[J]. Journal of China Pharmaceutical University, 2002, (2): 68-70.
    [9]Studies of Antivirus Activities of Eight Kinds of Chinese Medicinal Herb[J]. Journal of China Pharmaceutical University, 1995, (1): 33-36.
    [10]Study of Antibacterial and Antivirus of Mallotus furetianus[J]. Journal of China Pharmaceutical University, 1993, (4): 235-237.

Catalog

    Get Citation
    PDF
    XML
    Article views (1235) PDF downloads (1714) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：290294

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return