A new flavonoid glycoside from the stem barks of<i> Premna fulva</i>

WU Xueli; QI Chulu; WANG Hao; YE Wencai

doi:10.11665/j.issn.1000-5048.20160608

Journal of China Pharmaceutical University > 2016 > 47(6): 678-682. > DOI: 10.11665/j.issn.1000-5048.20160608

WU Xueli, QI Chulu, WANG Hao, YE Wencai. A new flavonoid glycoside from the stem barks of Premna fulva[J]. Journal of China Pharmaceutical University, 2016, 47(6): 678-682. DOI: 10.11665/j.issn.1000-5048.20160608

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A new flavonoid glycoside from the stem barks of Premna fulva

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A new flavonoid glycoside, named(2R)-naringenin-5-O-β-D- xylopyranosyl(1→6)-β-D-glucopyranoside( 1 ), together with other eight known compounds( 2-9 ), was isolated and characterized. Compounds 3-5 , 7-9 were isolated from the stem barks of Premna fulva for the first time. The anti-inflammatory activities of all the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide(NO)production in RAW 264. 7 macrophages cells. Compounds 2 , 6-9 exhibited moderate anti-inflammatory activities.
- Premna fulva,
- verbenaceae,
- chemical constituents,
- flavonoid,
- structural identification,
- nitric oxideinhibition

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A new flavonoid glycoside from the stem barks of Premna fulva

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