• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
YUE Juanjuan, CUI Hanyue, WANG Hui, YE Bin, CHEN Dingding. Protective effects of losartan potassium on 5/6 nephrectomy-induced chronic heart failure in rats[J]. Journal of China Pharmaceutical University, 2016, 47(6): 734-739. DOI: 10.11665/j.issn.1000-5048.20160617
Citation: YUE Juanjuan, CUI Hanyue, WANG Hui, YE Bin, CHEN Dingding. Protective effects of losartan potassium on 5/6 nephrectomy-induced chronic heart failure in rats[J]. Journal of China Pharmaceutical University, 2016, 47(6): 734-739. DOI: 10.11665/j.issn.1000-5048.20160617
shu

Protective effects of losartan potassium on 5/6 nephrectomy-induced chronic heart failure in rats

More Information
    Graphical Abstract
    • Abstract
  • The purpose of this research is to investigate the therapeutic effects of losartan potassium on 5/6 nephrectomy rats with chronic heart failure(CHF)and to explore the mechanism. 24 Rats were randomly divided into three groups namely sham group(Sham), pathology group(Nx)and losartan potassium group(Lst), respectively. CHF model in rats were induced by 5/6 nephrectomy. At the 7th week, rats of Lst group were given losartan potassium(50 mg/L)for consecutive 2 weeks. Then all rats were measured for hemodynamic parameters, cardiac index, creatinine, urea nitrogen in serum, and expressions of CD133, VEGFR2, Sox2, cleaved Caspase-3 and Bcl-2 in heart. Compared with Nx group, rats of Lst group improved cardiac and renal functions: decreased LVDP, LVEDP, cardiac index, creatinine, urea nitrogen and increased LVSP. Furthermore, losartan potassium up-regulated gene expression of CD133, VEGFR2, Sox2 and protein level of Bcl-2, and down-regulated cleaved Caspase-3 protein expression. Results suggest that losartan potassium can improve cardiac function of rats with CHF which may be correlated with mobilizing bone marrow stem cells, increasing endothelial progenitor cells(EPCs)level in heart, repairing endothelial function, and inhibiting myocardial apoptosis.
    • FullText(HTML)
    • References (16)
  • [1]
    Unger T,Li J.The role of the renin-angiotensin-aldosterone system in heart failure[J].J Renin Angiotensin Aldosterone Syst,2004,5(Suppl 1):S7-10.
    [2]
    Lund L,Benson L.Losartan vs candesartan for heart failure[J].JAMA,2012,308(4):336-337.
    [3]
    Wang JJ,Chen DD.Cardiorenal syndrome in 5/6 nephrectomized rats[J].Chin J Mod Drug Appl(中国现代药物应用),2009,3(15):1-4.
    [4]
    Remuzzi G,Perico N,Macia M,et al.The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease[J].Kidney Int,2005,68(Suppl 99):S57-65.
    [5]
    Zhao YH,Lu CX,Lei T,et al.The study of angiotensin Ⅱ inducing apoptosis in neonatal rat cardiomyocytes[J].Molecular Cardiol China(中国分子心脏病学杂志),2008,8(2):83-86.
    [6]
    Drexler H.Endothelium as a therapeutic target in heart failure[J].Circulation,1998,98(24):2652-2655.
    [7]
    Thal M,Krishnamurthy P,Mackie A,et al.Enhanced angiogenic and cardiomyocyte differentiation capacity of epigenetically reprogrammed mouse and human endothelial progenitor cells augments their efficacy for ischemic myocardial repair[J].Circ Res,2012,111(2):180-190.
    [8]
    Imanishi T,Hano T,Nishio I.Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress[J].J Hypertens,2005,23(1):97-104.
    [9]
    Endtmann C, Ebrahimian T, Czech T, et al. AngiotensinⅡ impairs endothelial progenitor cell number and function in vitro and in vivo:implications for vascular regeneration[J].Hypertension,2011,58(3):394-403.
    [10]
    Takahashi K,Yamanaka S.Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors[J].Cell,2006,126(4):663-676.
    [11]
    Rao JH,Zhou X.The key cell factors of stem cells Oct4 and Sox2[J].Prog Veterinary Med(动物医学进展),2012,33(3):114-119.
    [12]
    Liu C,Rong LM,Liu B.Sox2 induce mouse embryonic fibroblasts direct reprogrammin into neural stem cells[J].Chin J Pathophysiol(中国病理生理杂志),2015,31(1):87-92.
    [13]
    Tilling L,Chowienczyk P,Clapp B.Progenitors in motion:the mechanisms of mobilization of endothelial progenitor cells[J].Br J Clin Pharmacol,2009,68(4):484-492.
    [14]
    Kasal DA, Schiffrin EL. Angiotensin II, aldosterone, and anti-inflammatory lymphocytes:interplay and therapeutic opportunities[J].Int J Hypertens,2012,2012:829786.
    [15]
    Marumo T,Uchimura H,Hayashi M,et al.Aldosterone impairs bone marrow-derived progenitor cell formation[J].Hypertension,2006:48(3):490-496.
    [16]
    Yu Y,Fukuda N,Yao EH,et al.Effects of an ARB on endothelial progenitor cell function and cardiovascular oxidation in hypertension[J].Am J Hypertens,2008,21(1):72-77.
    • Related Articles

  • Related Articles

    [1]LI Wei, XU Xuefen. Mechanism of resveratrol induced apoptosis on human prostate cancer cell line DU145[J]. Journal of China Pharmaceutical University, 2018, 49(6): 711-717. DOI: 10.11665/j.issn.1000-5048.20180612
    [2]CHEN Jianping, REN Xinsheng, SUN Zhonghua, GUO Zaiyu. Protective effects and mechanisms of breviscapine on endothelial cells[J]. Journal of China Pharmaceutical University, 2015, 46(5): 610-616. DOI: 10.11665/j.issn.1000-5048.20150516
    [3]SUN Hao, YANG Jiapei, MAO Yong, WANG Dandan, YU Feng. Involvement of Fas-dependent pathway in rhein-induced apoptosis of HK-2 cells[J]. Journal of China Pharmaceutical University, 2015, 46(4): 469-475. DOI: 10.11665/j.issn.1000-5048.20150414
    [4]ZHANG Xiaoling, LI Aiping, HUAN Fei, QIN Heng, DUAN Jin′ao. Effects of celastrol on the proliferation and apoptosis of human leukemia cells HL-60 and Jurkat[J]. Journal of China Pharmaceutical University, 2015, 46(1): 89-93. DOI: 10.11665/j.issn.1000-5048.20150113
    [5]WANG Yu, ZHAO Li, MIAO Hanchi, LI Zhiyu, GUO Qinglong. Apoptosis induction of oroxylin A in human chronic myelogenous leukemia cell line K562[J]. Journal of China Pharmaceutical University, 2014, 45(2): 232-236. DOI: 10.11665/j.issn.1000-5048.20140218
    [6]QI Cuiling, ZHOU Xinlei, YE Jie, YANG Yang, ZHANG Qianqian, LI Jiangchao, WANG Lijing. Andrographolide induces Tb cell apoptosis by activating Caspase-3/PARP[J]. Journal of China Pharmaceutical University, 2013, 44(6): 559-562. DOI: 10.11665/j.issn.1000-5048.20130614
    [7]REN Jie, XIN Wenqun, CHEN Xin, HU Kun. Apoptosis induced by podophyllotoxin derivative OAMDP in HeLa cells[J]. Journal of China Pharmaceutical University, 2013, 44(3): 267-271. DOI: 10.11665/j.issn.1000-5048.20130316
    [8]LEI Hui, TAN Jiani, LI Shaoping, LI Haitao, JI Hui. Turmeric oil induces human hepatoma cell apoptosis via mitochondrial pathway[J]. Journal of China Pharmaceutical University, 2013, 44(3): 263-266. DOI: 10.11665/j.issn.1000-5048.20130315
    [9]GUO Zhong, ZHAO Jin, MA Jian-xiu, FU Si-wu. Effects of toxin A from Clostridium difficile on SMMC-7721 cells proliferation and apoptosis[J]. Journal of China Pharmaceutical University, 2009, 40(3): 250-253.
    [10]Mechanism of TNF Related Apoptosis Inducing Ligand Inducing Apoptosis and Its Pharmaceutical Exploitation[J]. Journal of China Pharmaceutical University, 2004, (4): 91-94.

Catalog

    Get Citation
    PDF
    XML
    Article views (589) PDF downloads (930) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    Copyright © Journal of China Pharmaceutical University苏ICP备12050101号-2

    Address：24 Tongjia Lane, Nanjing City, Jiangsu Province （210009）Tel: 025-83271566E-mail: xuebao@cpu.edu.cn

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    Total visits：302626

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return