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TANG Chunlei, FENG Bainian. AF-HF001-induced positive inotropic and electrocardiac effect in normal isolated rat hearts[J]. Journal of China Pharmaceutical University, 2017, 48(1): 66-69. DOI: 10.11665/j.issn.1000-5048.20170110
Citation: TANG Chunlei, FENG Bainian. AF-HF001-induced positive inotropic and electrocardiac effect in normal isolated rat hearts[J]. Journal of China Pharmaceutical University, 2017, 48(1): 66-69. DOI: 10.11665/j.issn.1000-5048.20170110
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AF-HF001-induced positive inotropic and electrocardiac effect in normal isolated rat hearts

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  • In this study, normal isolated rat heart model was adopted to investigate the inotropic and electrocardiac effect of AF-HF001 with Lanfendorff technique on the left ventricular systolic pressure(LVSP), left ventricular end diastolic pressure(LVEDP), peak rate of rise of left ventricular pressure(+dp/dtmax)and peak rate of fall of left ventricular pressure(-dp/dtmax). The results indicated that AF-HF001 could significantly enhance LVSP, LVEDP and ±dp/dtmax in a dose-dependent manner and exerted a positive inotropic effect on normal isolated rat hearts. This study also analyzed the electrocardiac effect of AF-HF001 with the electrodes located on tip of heart, ventricular free wall and aortic root. The results exhibited that AF-HF001 did not change PR, QRS, QT or HR at various concentrations, which means that AF-HF001 could safely increase cardiac contractility. This research lays a good foundation for the further study on AF-HF001 and research on structure-activity relationship of its analogs.
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  • [1]
    Cohn JN,Goldstein SO,Greenberg BH,et al. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure[J].N Engl J Med,1999,339(25):1810-1816.
    [2]
    Tang CL,Xie DS,Feng BN.A novel therapeutic approach for systolic heart failure:cardiac myosin activators[J].Chin J New Drugs(中国新药杂志),2013,22(16):1916-1920.
    [3]
    Tamargo J, López-Sendón J. Novel therapeutic targets for the treatment of heart failure[J].Nat Rev Drug Discov,2011,10(7):536-555.
    [4]
    Spirito P,Seidman CE,McKenna WJ,et al. The management of hypertrophic cardiomyopathy[J].N Engl J Med,1997,336(11):775-785.
    [5]
    Packer M,Carver JR,Rodeheffer RJ,et al. Effect of oral milrinone on mortality in severe chronic heart failure[J].N Engl J Med,1991,325(21):1468-1475.
    [6]
    Malik FI,Morgan BP.Cardiac myosin activation part 1:from concept to clinic[J].J Mol Cell Cardiol,2011,51(4):454-461.
    [7]
    Malik FI,Hartman JJ,Elias KA,et al. Cardiac myosin activation:a potential therapeutic approach for systolic heart failure[J].Science,2011,331(6023):1439-1443.
    [8]
    Cleland JG,Teerlink JR,Senior R,et al. The effects of the cardiac myosin activator,omecamtiv mecarbil,on cardiac function in systolic heart failure:a double-blind,placebo-controlled,crossover,dose-ranging phase 2 trial[J].Lancet,2011,378(9792):676-683.
    [9]
    Morgan BP,Muci A,Lu PP,et al. Discovery of omecamtiv mecarbil the first,selective,small molecule activator of cardiac Myosin[J].ACS Med Chem Lett,2010,1(9):472-477.
    [10]
    Hao AT,Lin F,Greenberg BH.Potential new drug treatments for congestive heart failure[J].Expert Opin Investig Drugs,2016,25(7):811-826.
    [11]
    Tang CL,Xie DS,Feng BN.Zebrafish as a new model for phenotype-based screening of positive inotropic agents[J].Chem Biol Drug Des,2015,85(3):253-258.
    [12]
    Wang GP,Tang CL,Yan GJ,et al.Gene expression profiling of H9c2 cells subjected to H2O2-induced apoptosis with/without AF-HF001[J].Biol Pharm Bull,2016,39(2):207-214.
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