Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway

WANG Xue; ZHANG Pinghu

doi:10.11665/j.issn.1000-5048.20170117

Journal of China Pharmaceutical University > 2017 > 48(1): 110-116. > DOI: 10.11665/j.issn.1000-5048.20170117

WANG Xue, ZHANG Pinghu. Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway[J]. Journal of China Pharmaceutical University, 2017, 48(1): 110-116. DOI: 10.11665/j.issn.1000-5048.20170117

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Advances in research on the modulation of autophagy by Ras/Raf/MEK/ERK signaling pathway

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Abstract

Autophagy is a conserved self-defense mechanism of organism, degrading the necrotic organelles and excess protein into small molecules for recycling. Autophagy plays a role in both physiological and pathological condition, influencing the expression of intracellular substance through multiple signaling pathways. Although it has been demonstrated that Ras/Raf/MEK/ERK signaling pathway was not only extensively involved in the regulation of cell growth, proliferation, differentiation and apoptosis, but was also implicated in autophagy and autophagic cell death, though its detailed mechanisms involved in regulation of autophagy has not been fully elucidated yet. This review focused on the advances of autophagy induced by Ras/Raf/MEK/ERK signaling pathway, to better understand the role of Ras/Raf/MEK/ERK signaling pathway in regulation of autophagy.
- Ras/Raf/MEK/ERK pathway,
- autophagy,
- B-Raf,
- K-Ras,
- anti-tumor

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[1]	Kabeya Y,Kawamata T,Suzuki K,et al.Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae[J].Biochem Biophys Res Commun,2007,356(2):405-410.
[2]	Hu Z,Yang B,Mo X,et al.Mechanism and regulation of autophagy and its role in neuronal diseases[J].Mol Neurobiol,2015,52(3):1190-1209.
[3]	Ropolo A,Grasso D,Pardo R,et al.The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells[J].J Biol Chem,2007,282(51):37124-37133.
[4]	Tarantino G,Capone D.Inhibition of the mTOR pathway:a possible protective role in coronary artery disease[J].Ann Med, 2013,45(4):348-356.
[5]	Huang YC, Yu HS, Chai CY. Roles of oxidative stress and the ERK1/2,PTEN and p70S6K signaling pathways in arsenite-induced autophagy[J].Toxicol Lett,2015,239(3):172-181.
[6]	Jung CH,Jun CB,Ro SH,et al.ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery[J].Mol Biol Cell,2009,20(7):1992-2003.
[7]	Xie ZG,Xie Y,Dong QR.Inhibition of the mammalian target of rapamycin leads to autophagy activation and cell death of MG63 osteosarcoma cells[J].Oncol Lett,2013,6(5):1465-1469.
[8]	Zhao YY,Tian Y,Zhang J,et al.Effects of an oral allosteric AKT inhibitor(MK-2206)on human nasopharyngeal cancer in vitro and in vivo[J].Drug Des Devel Ther,2014,8:1827-1837.
[9]	Xing C,Zhu B,Liu H,et al.Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901[J].Acta Biochim Biophys Sin(Shanghai),2008,40(3):194-201.
[10]	Ding Q,Gu R,Liang J,et al.PI-103 sensitizes acute myeloid leukemia stem cells to daunorubicin-induced cytotoxicity[J].Med Oncol,2013,30(1):395.
[11]	Zhao L,Teng B,Wen L,et al.mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma[J].Int J Clin Exp Med,2014,7(2):337-347.
[12]	Wu T,Wang MC,Jing L,et al.Autophagy facilitates lung adenocarcinoma resistance to cisplatin treatment by activation of AMPK/mTOR signaling pathway[J].Drug Des Devel Ther,2015,9:6421-6431.
[13]	Sun A,Li C,Chen R,et al.GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells[J].Prostate,2016,76(2):172-183.
[14]	Fan XY,Tian C,Wang H,et al.Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection[J].Sci Rep,2015,5:14728.
[15]	Liang J,Shao SH,Xu ZX,et al.The energy sensing LKB1-AMPK pathway regulates p27(kip1)phosphorylation mediating the decision to enter autophagy or apoptosis[J].Nat Cell Biol,2007,9(2):218-224.
[16]	Kumar B,Iqbal MA,Singh RK,et al.Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy[J].Biochimie,2015,118:26-35.
[17]	Zhu Y,Zhou J,Ao R,et al.A-769662 protects osteoblasts from hydrogen dioxide-induced apoptosis through activating of AMP-activated protein kinase(AMPK)[J].Int J Mol Sci,2014,15(6):11190-11203.
[18]	Wu Y,Qi Y,Liu H,et al.AMPK activator AICAR promotes 5-FU-induced apoptosis in gastric cancer cells[J].Mol Cell Biochem,2016,411(1/2):299-305.
[19]	Vucicevic L,Misirkic M,Janjetovic K,et al.Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway[J].Autophagy,2011,7(1):40-50.
[20]	Wang C,Chen K,Xia Y,et al.N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway[J].PLoS ONE,2014,9(9):e108855.
[21]	Pattingre S,Bauvy C,Carpentier S,et al.Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy[J].J Biol Chem,2009,284(5):2719-2728.
[22]	Wu H,Wang MC,Bohmann D.JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy[J].Mech Dev,2009,126(8-9):624-637.
[23]	Li JP,Yang YX,Liu QL,et al.The investigational Aurora kinase A inhibitor alisertib(MLN8237)induces cell cycle G2/M arrest,apoptosis,and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells[J].Drug Des Devel Ther,2015,9:1627-1652.
[24]	Han R,Liang H,Qin ZH,et al.Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway[J].Acta Pharmacol Sin,2014,35(10):1323-1332.
[25]	Grossi V, Liuzzi M, Murzilli S, et al. Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response[J].Cancer Biol Ther,2012,13(14):1471-1481.
[26]	Patnaik A,Haluska P,Tolcher AW,et al.A first-in-human phase I study of the oral p38 MAPK inhibitor,ralimetinib(LY2228820 Dimesylate),in patients with advanced cancer[J].Clin Cancer Res,2016,22(5):1095-1102.
[27]	Lee CH,Lin SH,Chang SF,et al.Extracellular signal-regulated kinase 2 mediates the expression of granulocyte colony-stimulating factor in invasive cancer cells[J].Oncol Rep,2013,30(1):419-424.
[28]	Kim JH,Hong SK,Wu PK,et al.Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels[J].Exp Cell Res,2014,327(2):340-352.
[29]	Sivaprasad U, Basu A. Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-α-induced cell death in MCF-7 cells[J].J Cell Mol Med,2008,12(4):1265-1271.
[30]	Chang CY,Li JR,Wu CC,et al.Valproic acid sensitizes human glioma cells to gefitinib-induced autophagy[J].IUBMB Life,2015,67(11):869-879.
[31]	Xu Z, Hang J, Hu J, et al. Gefitinib,an EGFR tyrosine kinase inhibitor,activates autophagy through AMPK in human lung cancer cells[J].J BUON.2014,19(2):466-473.
[32]	Ouyang L,Chen Y,Wang XY,et al.Polygonatum odoratum lectin induces apoptosis and autophagy via targeting EGFR-mediated Ras-Raf-MEK-ERK pathway in human MCF-7 breast cancer cells[J].Phytomedicine,2014,21(12):1658-1665.
[33]	Li X,Fan Z.The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex[J].Cancer Res,2010,70(14):5942-5952.
[34]	Schmukler E, Grinboim E, Schokoroy S, et al. Ras inhibition enhances autophagy,which partially protects cells from death[J].Oncotarget,2013,4(1):145-155.
[35]	Labouba I,Poisson A,Lafontaine J,et al.The RelB alternative NF-kappaB subunit promotes autophagy in 22Rv1 prostate cancer cells in vitro and affects mouse xenograft tumor growth in vivo[J].Cancer Cell Int,2014,14(1):67.
[36]	Zhao Y, Chen H, Shang Z, et al. SD118-xanthocillin X(1),a novel marine agent extracted from Penicillium commune,induces autophagy through the inhibition of the MEK/ERK pathway[J].Mar Drugs,2012,10(6):1345-1359.
[37]	Mareninova OA,Sendler M,Malla SR,et al.Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis:LAMP-2 deficient mice develop pancreatitis[J].Cell Mol Gastroenterol Hepatol,2015,1(6):678-694.
[38]	Liu YL,Lai F,Wilmott JS,et al.Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells[J].Oncotarget,2014,5(22):11237-11251.
[39]	Ni ZH,Wang B,Ding W,et al.(-)-Gossypol induces autophagy in Daudi cells through ERK signal pathway[J].J Third Mil Med Univ(第三军医大学学报),2012,34(23):2384-2387.
[40]	Zucchini-Pascal N,de Sousa G,Rahmani R.Lindane and cell death:at the crossroads between apoptosis,necrosis and autophagy[J].Toxicology,2009,256(1/2):32-41.
[41]	Chen KL,Chang WS,Cheung CH,et al.Targeting cathepsin S induces tumor cell autophagy via the EGFR-ERK signaling pathway[J].Cancer Lett,2012,317(1):89-98.
[42]	Wang X,Martindale JL,Holbrook NJ.Requirement for ERK activation in cisplatin-induced apoptosis[J].J Biol Chem,2000,275(50):39435-39443.
[43]	Cagnol S,Van Obberghen-Schilling E,Chambard JC.Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death[J].Apoptosis,2006,11(3):337-346.

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