Advances in antidiabetic small molecule ABHD6 inhibitors

SI Lianghui; MA Hui; ZHOU Jinpei; ZHANG Huibin

doi:10.11665/j.issn.1000-5048.20170201

Journal of China Pharmaceutical University > 2017 > 48(2): 125-134. > DOI: 10.11665/j.issn.1000-5048.20170201

SI Lianghui, MA Hui, ZHOU Jinpei, ZHANG Huibin. Advances in antidiabetic small molecule ABHD6 inhibitors[J]. Journal of China Pharmaceutical University, 2017, 48(2): 125-134. DOI: 10.11665/j.issn.1000-5048.20170201

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Advances in antidiabetic small molecule ABHD6 inhibitors

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Abstract

Type 2 diabetes, a glucose and lipid metabolism disorder accompanied by chronic multiple organ damage, has become a huge threat to human health. α/β hydrolase domain-6(ABHD6)regulates the insulin release negatively by hydrolyzing monoacylglycerol. Small molecule ABHD6 inhibitors have been proven to lower blood-glucose and regulates energy homeostasis, which is a potential candidate for the treatment of type 2 diabetes. This paper introduced the ABHD6 signaling pathway and its mechanism, then reviewed the progress of small molecule ABHD6 inhibitors with different structures in recent years, and analyzed the structure activity relationship.
- glucose and lipid metabolism,
- α/β hydrolase domain-6,
- ABHD6 inhibitors,
- antidiabetic drugs,
- advances

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