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LIU Yuan, ZHOU Jianping, WANG Wei. Advances in PEGylated targeted nano-preparation[J]. Journal of China Pharmaceutical University, 2017, 48(3): 268-275. DOI: 10.11665/j.issn.1000-5048.20170303
Citation: LIU Yuan, ZHOU Jianping, WANG Wei. Advances in PEGylated targeted nano-preparation[J]. Journal of China Pharmaceutical University, 2017, 48(3): 268-275. DOI: 10.11665/j.issn.1000-5048.20170303
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Advances in PEGylated targeted nano-preparation

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    • Abstract
  • Polyethylene glycol(PEG)with good hydrophilicity and flexibility can improve pharmacokinetic and pharmacodynamic properties of the nano-preparation, so PEG modification in the surface of nano-preparation can increase the in vivo residence time and concentration of drugs. At present, the targeted nano-preparation with PEG modification has become a research hotspot in the field of pharmaceutics. In this paper, the physical and chemical methods of PEG modification in targeted nano-preparation was summarized, which includes physically inserting PEG-lipid derivatives in nanostructure of targeted nano-preparation or modifying PEG with targeted nano-preparation. In addition, the influence of PEG parameters(molecular mass, modified density and spatial conformation)on properties of targeted nano-preparation was also discussed, which is important to preferably structure PEGylated targeted nano-preparation.
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