Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment

SUN Jingfang; GUO Chunjing; ZHANG Yunduan; SONG Xiaoyan; LYU Jiantao; YIN Jungang; CHEN Daquan

doi:10.11665/j.issn.1000-5048.20170309

Journal of China Pharmaceutical University > 2017 > 48(3): 305-310. > DOI: 10.11665/j.issn.1000-5048.20170309

SUN Jingfang, GUO Chunjing, ZHANG Yunduan, SONG Xiaoyan, LYU Jiantao, YIN Jungang, CHEN Daquan. Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment[J]. Journal of China Pharmaceutical University, 2017, 48(3): 305-310. DOI: 10.11665/j.issn.1000-5048.20170309

Citation:

PDF (1292 KB)

Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment

More Information

Graphical Abstract

Abstract

Abstract

In order to construct a novel multifunctional targeting nano-carrier based on pH-redox characteristics of tumor microenvironment, ketone bonds and disulfide bonds were bonded to the oligomeric hyaluronic acid(oHA)being sensitive to pH and the reduction environment. The chemical structure of oligomeric hyaluronic acid-8-mercaptomenthone 1, 2-glycerolketal(oHMST)was characterized by ¹H NMR, IR and ESI-MS. Curcumin-loaded micelles were prepared by dialysis. The single factor investigation was carried out on the dosage form. Some properties, including particle size zeta potential, the morphology of micelles, and pH-sensitivity were studied. The materials were synthesized successfully. The micelles were spheric with a diameter of about 100 nm. The Zeta potential of the micelles was -(21. 97±1. 08)mV. The in vitro test showed that oHMST carriers have good pH-sensitivity and redox-sensitivity.
- pH-sensitivity,
- redox-sensitivity,
- targeting carrier,
- micelles,
- tumor microenviroment,
- preparation,
- characterization

FullText(HTML)

References (13)

References

[1]	Chen D,Wang H.Novel pH-sensitive biodegradable polymeric drug delivery systems based on ketal polymers[J].J Nanosci Nanotechnol,2014,14(1):983-989.
[2]	Yu Y,Zhang X,Qiu L.The anti-tumor efficacy of curcumin when delivered bysize/charge-changing multistage polymeric micelles based on amphiphilic poly(β-amino ester)derivates[J].Biomaterials,2014,35(10):3467-3479.
[3]	Fang J,Nakamura H,Maeda H.The EPR effect:unique features of tumor blood vessels for drug delivery,factors involved,and limitations and augmentation of the effect[J].Adv Drug Deliv Rev,2011,63(3):136-151.
[4]	Kesharwani P,Banerjee S,Padhye S,et al.Hyaluronic acid engineered nanomicelles loaded with 3,4-difluorobenzylidene curcumin for targeted killing of CD44+ stem-like pancreatic cancer cells[J].Biomacromolecules,2015,16(9):3042-3053.
[5]	Li YN,Wang J,Li J,et al.Co-delivery of siRNA and docetaxel by hyaluronic acid modified redox-sensitive dissulfide-crosslinked nanoparticles[J].J China Pharm Univ(中国药科大学学报),2016,47(4):429-436.
[6]	Cheng R, Feng F, Meng F, et al. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery[J].J Control Release,2011,152(1):2-12.
[7]	Wei H,Zhuo R X,Zhang X Z.Design and development of polymeric micelles with cleavable links for intracellular drug delivery[J].Prog Polym Sci,2013,38(3):503-535.
[8]	Guo X,Shi C,Wang J,et al.pH-triggered intracellular release from actively targeting polymer micelles[J].Biomaterials,2013,34(18):4544-4554.
[9]	Katayama Y,Sonoda T,Maeda M.A polymer micelle responding to the protein kinase A signal[J].Macromolecules,2001,34(24):8569-8573.
[10]	Rapoport N.Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery[J].Prog Polym Sci,2007,32(8):962-990.
[11]	Lian S, Sun J, Sun K, et al. Preparation and characterization of oligomeric hyaluronic acid-ketal as a tumour CD44 receptor and pH-sensitive targeting carrier [J].J China Pharm Univ(中国药科大学学报),2014,45(5):540-543.
[12]	Chen D,Sun J,Sun K,et al.In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers[J].Artif Cells Nanomed Biotechnol,2016,4(3):898-902.
[13]	Shi C,Guo X,Qu Q,et al.Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles[J].Biomaterials,2014,35(30):8711-8722.

Cited By

Get Citation

PDF

XML

Article views (1130) PDF downloads (2045)

Turn off MathJax

Article Contents

Abstract

References

Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment

Abstract

References

Catalog

Export File

Citation

Format

Content