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SUN Jingfang, GUO Chunjing, ZHANG Yunduan, SONG Xiaoyan, LYU Jiantao, YIN Jungang, CHEN Daquan. Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment[J]. Journal of China Pharmaceutical University, 2017, 48(3): 305-310. DOI: 10.11665/j.issn.1000-5048.20170309
Citation: SUN Jingfang, GUO Chunjing, ZHANG Yunduan, SONG Xiaoyan, LYU Jiantao, YIN Jungang, CHEN Daquan. Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment[J]. Journal of China Pharmaceutical University, 2017, 48(3): 305-310. DOI: 10.11665/j.issn.1000-5048.20170309
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Preparation and characterization of multi-functional targeting nano-carrier based on pH-redox tumor microenvironment

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  • In order to construct a novel multifunctional targeting nano-carrier based on pH-redox characteristics of tumor microenvironment, ketone bonds and disulfide bonds were bonded to the oligomeric hyaluronic acid(oHA)being sensitive to pH and the reduction environment. The chemical structure of oligomeric hyaluronic acid-8-mercaptomenthone 1, 2-glycerolketal(oHMST)was characterized by 1H NMR, IR and ESI-MS. Curcumin-loaded micelles were prepared by dialysis. The single factor investigation was carried out on the dosage form. Some properties, including particle size zeta potential, the morphology of micelles, and pH-sensitivity were studied. The materials were synthesized successfully. The micelles were spheric with a diameter of about 100 nm. The Zeta potential of the micelles was -(21. 97±1. 08)mV. The in vitro test showed that oHMST carriers have good pH-sensitivity and redox-sensitivity.
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