Synthesis and inhibition of NO production activities of 1, 6-<i>O</i>, <i>O</i>-diacylbritannilactone derivatives

ZHU Hong; WEI Xiaopeng; JIN Meihua; QIN Nan

doi:10.11665/j.issn.1000-5048.20170408

Journal of China Pharmaceutical University > 2017 > 48(4): 440-444. > DOI: 10.11665/j.issn.1000-5048.20170408

ZHU Hong, WEI Xiaopeng, JIN Meihua, QIN Nan. Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives[J]. Journal of China Pharmaceutical University, 2017, 48(4): 440-444. DOI: 10.11665/j.issn.1000-5048.20170408

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Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives

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Eight 1, 6-O, O-diacetylbritannilactone(OABL)derivatives(compounds 1 - 8 )were synthesized by esterification or reduction of 1-O-diacetylbritannilactone(ABL)isolated from Inula japonica. All derivatives were evaluated for their anti-inflammation activities through the determination of inhibition of nitric oxide(NO)production in lipopolysaccharide(LPS)-induced macrophages. As results, compounds 5 - 8 (IC₅₀< 2 μmol/L)exhibited more potent inhibition of NO production activities than the lead compound OABL.
- 1,6-O,O-diacylbritannilactone,
- derivatives,
- synthesis,
- nitrogen monoxide,
- anti-inflammation activities

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Synthesis and inhibition of NO production activities of 1, 6-O, O-diacylbritannilactone derivatives

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