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LI Xiaodi, GUO Xinglong, DAI Rongji, LYU Fang, CONG Lin, DENG Yulin. Synthesis and activities of derivatives of magnolol and honokiol[J]. Journal of China Pharmaceutical University, 2017, 48(5): 536-542. DOI: 10.11665/j.issn.1000-5048.20170505
Citation: LI Xiaodi, GUO Xinglong, DAI Rongji, LYU Fang, CONG Lin, DENG Yulin. Synthesis and activities of derivatives of magnolol and honokiol[J]. Journal of China Pharmaceutical University, 2017, 48(5): 536-542. DOI: 10.11665/j.issn.1000-5048.20170505
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Synthesis and activities of derivatives of magnolol and honokiol

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    • Abstract
  • Based on the chemical structures of magnolol and honokiol, a series of small molecular derivatives were designed for the treatment of Alzheimer′s disease. Through the Discovery Studio, five compounds( 6a - 6e )exhibited the inhibitory activity against Aβ and Tau proteins in all of the designed compounds. Then the five compounds are chemically synthesized and their biological activities were tested by thioflavin T. The result showed that compound 6a had inhibitory effect on the aggregation of two kinds of target proteins at the concentration of 100 μmol/L, which deserves further research.
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    • References (21)
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