Alkaloid constituents from<i> Corydalis decumbens</i>

HUANG Qilong; ZHANG Wanjin; LI Yan; CHEN Juan; ZHOU Baoping; ZOU Xiaohan; ZHANG Chunlei; CAO Zhengyu

doi:10.11665/j.issn.1000-5048.20170509

Journal of China Pharmaceutical University > 2017 > 48(5): 563-567. > DOI: 10.11665/j.issn.1000-5048.20170509

HUANG Qilong, ZHANG Wanjin, LI Yan, CHEN Juan, ZHOU Baoping, ZOU Xiaohan, ZHANG Chunlei, CAO Zhengyu. Alkaloid constituents from Corydalis decumbens[J]. Journal of China Pharmaceutical University, 2017, 48(5): 563-567. DOI: 10.11665/j.issn.1000-5048.20170509

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Alkaloid constituents from Corydalis decumbens

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Abstract

To study alkaloid constituents in Corydalis decumbens, thirteen compounds were isolated from 95% ethanol extracts of Corydalis decumbens(Thunb)Pers. by silica gel, RP-C₁₈, Sephadex LH-20 column chromatographer, recry stallization, thin-layer chromatography and HPLC. Their structures were elucidated on the basis of spectral data combined with physiochemical properties as tetrahydropalmatine( 1 ), oxyhydrastinine( 2 ), doryanine( 3 ), palmatine( 4 ), bicuculline( 5 ), canadine( 6 ), tetrahydrocoptisine( 7 ), corydaldine( 8 ), epicorynoxidine( 9 ), N-methylcorydaldine( 10 ), (+)-corlumine( 11 ), N-methyl-6, 7-dimethoxyisoquinolone( 12 )and oxysanguinarine( 13 ). Compounds 2 , 3 , 6 , 7 , and 9 - 13 were isolated from this plant for the first time. In addition, compounds 2 , 3 , and 9 - 13 were obtained firstly from this genus. Pharmacological experiments showed that tetrahydropalmatine( 1 )might have analgesic or sedative effects, and the bicuculline( 5 )could probably induce epilepsy.
- Corydalis decumben,
- tubers,
- chemical constituents,
- alkaloid,
- isolation and identification

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