• 中国精品科技期刊
  • 中国高校百佳科技期刊
  • 中国中文核心期刊
  • 中国科学引文数据库核心期刊
Advanced Search
CHENG Weihua, WANG Wenqian, SHANG Hai, ZHANG Hongwu, GUO Qiang, CHEN Hong, ZOU Zhongmei. Synthesis and cytotoxicity study of cembrane triazole derivatives[J]. Journal of China Pharmaceutical University, 2018, 49(1): 56-63. DOI: 10.11665/j.issn.1000-5048.20180108
Citation: CHENG Weihua, WANG Wenqian, SHANG Hai, ZHANG Hongwu, GUO Qiang, CHEN Hong, ZOU Zhongmei. Synthesis and cytotoxicity study of cembrane triazole derivatives[J]. Journal of China Pharmaceutical University, 2018, 49(1): 56-63. DOI: 10.11665/j.issn.1000-5048.20180108

Synthesis and cytotoxicity study of cembrane triazole derivatives

More Information
  • A series of triazole derivatives were designed and synthesized based on a natural product cembrane separated from Croton laevigatus Vahl which showed potential antitumor activity against HeLa cells. Twelve novel compounds were synthesized and their structures were characterized by 1H NMR, 13C NMR and HRMS. Their cytotoxicities in vitro were evaluated for HeLa, K562 and K562/A02 cells by MTT assay. The results showed that some cembrane derivatives possessed antitumor activities. Substituted triazole connected to cembrane derivatives exhibited potent activity toward drug-resistant K562/A02 cells.
  • [1]
    Thao NP,Luyen BTT,Ngan NTT,et al.New anti-inflammatory cembranoid diterpenoids from the Vietnamese soft coral Lobophytum crassum[J].Bioorg Med Chem Lett,2014,24(1):228-232.
    [2]
    Peres MT,Delle Monache F,Cruz AB,et al.Chemical composition and antimicrobial activity of Croton urucurana Baillon(Euphorbiaceae)[J].J Ethnopharmacol,1997,56(3):223-226.
    [3]
    Tsacheva I,Rostan J,Iossifova T,et al.Complement inhibiting properties of dragon′s blood from Croton draco[J].Z Naturforsch C,2004,59(7/8):528-532.
    [4]
    Su JH,Ahmed AF,Sung PJ,et al.Manaarenolides AI,diterpenoids from the soft coral Sinularia manaarensis[J].J Nat Prod,2006,69(8):1134-1139.
    [5]
    Hassan HM,Sallam AA,Mohammed R,et al.Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors[J].Bioorg Med Chem,2011,19(16):4928-4934.
    [6]
    Fahmy H,Zjawiony JK,Konoshima T,et al.Potent skin cancer chemopreventing activity of some novel semi-synthetic cembranoids from marine sources[J].Mar Drugs,2006,4(2):28-36.
    [7]
    Huang HC,Ahmed AF,Su JH,et al.Crassocolides A-F,cembranoids with a transfused lactone from the soft coral Sarcophyton crassocaule[J].J Nat Prod,2006,69(11):1554-1559.
    [8]
    Sánchez MC,Ortega MJ,Zubía E,et al.Cembrane diterpenes from the gorgonian Lophogorgia peruana[J].J Nat Prod,2006,69(12):1749-1755.
    [9]
    Wen T,Ding Y,Deng Z,et al.Sinulaflexiolides A-K,cembrane-type diterpenoids from the Chinese soft coral Sinularia flexibilis[J].J Nat Prod,2008,71(7):1133-1140.
    [10]
    Cuzick J.Anastrozole[J].Drugs Today,2005: 41(4):227-239.
    [11]
    Ribatti D,Vacca A,Falco GD,et al.Angiogenesis and anti-angiogenesis in neuroblastoma[J].Eur J Cancer,2002,38(6):750-757.
    [12]
    Guo L,Li ZS,Wang HL,et al.Carboxyamido-triazole inhibits proliferation of human breast cancer cell via G2/M cell cycle arrest and apoptosis[J].Eur J Pharmacol,2006,538(1/2/3):15-22.
    [13]
    Cheng WH,Cao B,Shang H,et al.Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents[J].Eur J Med Chem,2014,85:498-507.
    [14]
    Mahadevan D.Will MDR-1/P-gp modulators provide clinical benefit in hematologic malignancies[J]?Leuk Res,2006,30(9):1077-1078.

Catalog

    Article views (656) PDF downloads (1112) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return