Advances in drug delivery systems for the treatment of liver fibrosis

FAN Qianqian; XING Lei; QIAO Jianbin; ZHANG Chenglu; JIANG Hulin

doi:10.11665/j.issn.1000-5048.20180302

Journal of China Pharmaceutical University > 2018 > 49(3): 263-271. > DOI: 10.11665/j.issn.1000-5048.20180302

FAN Qianqian, XING Lei, QIAO Jianbin, ZHANG Chenglu, JIANG Hulin. Advances in drug delivery systems for the treatment of liver fibrosis[J]. Journal of China Pharmaceutical University, 2018, 49(3): 263-271. DOI: 10.11665/j.issn.1000-5048.20180302

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Advances in drug delivery systems for the treatment of liver fibrosis

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Abstract

Liver fibrosis is a major disease that affects human health. Currently, drugs used for the treatment of hepatic fibrosis have such problems as low drug solubility, lack of liver specificity and possible occurrence of side-effects. In order to improve the anti-fibrosis therapeutic efficacy, various nano-drug delivery systems and targeting strategies are explored in liver fibrosis therapy. This review summarizes the drug delivery systems and targeting strategies that have been applied to liver fibrosis therapy in recent years from the types of carriers and modified ligands, which serve as a basis of designing safe and effective drug delivery systems for liver fibrosis therapy.
- liver fibrosis,
- anti-fibrosis,
- nano-drug delivery systems,
- targeting strategies

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